ID Q2PFD9_PICPA Unreviewed; 1015 AA.
AC Q2PFD9;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PIK1 {ECO:0000313|EMBL:BAE73184.1};
OS Komagataella pastoris (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=4922 {ECO:0000313|EMBL:BAE73184.1};
RN [1] {ECO:0000313|EMBL:BAE73184.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16754956; DOI=10.1083/jcb.200512142;
RA Yamashita S., Oku M., Wasada Y., Ano Y., Sakai Y.;
RT "PI4P-signaling pathway for the synthesis of a nascent membrane structure
RT in selective autophagy.";
RL J. Cell Biol. 173:709-717(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; AB220683; BAE73184.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2PFD9; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 6.10.140.1260; -; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021601; Phosphatidylino_kinase_fungi.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR Pfam; PF11522; Pik1; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAE73184.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..119
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 720..998
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 240..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 114780 MW; 486F345C6E0A4899 CRC64;
MDQSGNALLL RFINSQHFNL YYCISYLQRY SDNIGVHHYL CEKVKTYPIE ELKFFIPQFL
QLIITVETDS MALEEMIKDL CTRDVHFSLI TFWHLQSSLQ ELSTQPNSTG FQVCKRILND
VQFQLFSLSP PNATVSSRVG SSGIVYKNSQ HAMKQFRENV SPSAVLISSV LSSAAFPQLG
KSAEHLVRTQ GKLSRSFVFQ IAKGLQQQMN ENLTMKNTRL NAELSSHTVV NAAELDASQA
EKPYRRAKSL SLTSLQGKRQ GQQDQHPKHN EHSENLDFSI IDKYAETNLP HLNRAISNPN
MKRFKNKRLS QALDVKQSVM SDLYPMSPEK GYDNLTLKNL QRLRSESQLN NDSITASMPE
LHPTHTNSTA VSEVESLYDS GNERSPTISL NGSYKRQPIK LSVPQKIKVL KNNYFKCETQ
FVIALQNISI KLSNVPKETR LACLRAELTL MNKDLPCEID VPLLLPNAKS GKLHKIVNIP
ANEAAVLNSA ERVPYLLLIE YVSNEVDFSP ESKENKQLLE RLNDNSSDVN GDSKRYVFDL
AGIMRASDSR RTNDYGKSMS TLQNGEMPLE ADLADLSIVN LSNRKESEFL KREQFVQAAS
EVPILEGDSP LRQDVLNFQS HYETDSLTDK SDFATQMRIA AVMLSQLDSS TSHLPMDQAG
AIKARIVSSM QSLQHEFGVK DLQDINTEAG ERKFSNDLKV AGVKSNLKNK NDYYLGEDWN
SKKERIRKQS PYGHLEHWNL CSVIAKTGDD LTQEAFACQL IQSMATVWHN HGVNIWVKRM
RILVTSNSTG LVETITDAVS IHSIKKSLTE YLIENNEDHR GAIATLLDHF RMTFGDPNSA
RYRKAQNNFA ISLAAYSVIC YILQIKDRHN GNIMLDNEGH IIHIDFGFLL SNSPGSVGFE
AAPFKLTLEY VDVLGGLDGE YFQVFKQSTK EAFKSLRRNA ESLITMVELM QRDSTLPCFK
AGENTSVQLR QRLQLHLSEE DSDYFVENFL IGKSIGSIYT KLYDQFQLLT QGIYS
//
