ID Q2PXW8_ONCMY Unreviewed; 304 AA.
AC Q2PXW8;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Solute carrier family 25 member 8 {ECO:0000256|ARBA:ARBA00042368};
GN Name=UCP2A {ECO:0000313|EMBL:ABC00183.1};
GN Synonyms=ucp2a {ECO:0000313|Ensembl:ENSOMYP00000100349.1};
GN ORFNames=GSONMT00078527001 {ECO:0000313|EMBL:CDQ58806.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:ABC00183.1};
RN [1] {ECO:0000313|EMBL:ABC00183.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16899121; DOI=10.1186/1471-2164-7-203;
RA Coulibaly I., Gahr S.A., Palti Y., Yao J., Rexroad C.E.III.;
RT "Genomic structure and expression of uncoupling protein 2 genes in rainbow
RT trout (Oncorhynchus mykiss).";
RL BMC Genomics 7:203-203(2006).
RN [2] {ECO:0000313|EMBL:CDQ58806.1, ECO:0000313|Proteomes:UP000193380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [3] {ECO:0000313|EMBL:CDQ58806.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSOMYP00000100349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; DQ295324; ABC00180.1; -; Genomic_DNA.
DR EMBL; DQ295326; ABC00183.1; -; mRNA.
DR EMBL; FR904311; CDQ58806.1; -; Genomic_DNA.
DR RefSeq; NP_001118126.1; NM_001124654.1.
DR STRING; 8022.Q2PXW8; -.
DR PaxDb; 8022-Q2PXW8; -.
DR Ensembl; ENSOMYT00000108885.2; ENSOMYP00000100349.1; ENSOMYG00000045400.2.
DR GeneID; 100136683; -.
DR KEGG; omy:100136683; -.
DR CTD; 100136683; -.
DR GeneTree; ENSGT00940000159524; -.
DR OrthoDB; 1832865at2759; -.
DR Proteomes; UP000193380; Chromosome 10.
DR Proteomes; UP000694395; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR PANTHER; PTHR45618:SF1; MITOCHONDRIAL UNCOUPLING PROTEIN 2; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 11..107
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 115..205
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 214..299
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 304 AA; 32691 MW; 2AFAFF87CF8FFCC3 CRC64;
MVGFRPADVP PTAAVKFIGA GTAACIADLF TFPLDTAKVR LQIQGEEKGA AASHGTAVRY
RGVFGTITTM VRTEGARSLY SGLVAGLQRQ MSFASIRIGL YDSVKSFYTK GSDHVGIGSR
LLAGCTTGAM AVALAQPTDV VKVRFQAQAS SSGPNRRYHG TMQAYKTIAK EEGMRGLWRG
TGPNIARNAI VNCTELVTYD LIKDALLKNT SLTDDLPCHF TSAFGAGFCT TVIASPVDVV
KTRYMNSALG QYSSTLNCAH AMVTKEGPLA FYKGFMPSFL RLGSWNVVMF VTYEQLKRAM
MAAR
//
