ID Q2Q4Z3_COLEU Unreviewed; 486 AA.
AC Q2Q4Z3;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE Flags: Fragment;
GN Name=PGI {ECO:0000313|EMBL:ABB76194.1};
OS Colias eurytheme (Orange sulphur butterfly) (Alfalfa caterpillar).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Pieridae; Coliadinae; Colias.
OX NCBI_TaxID=42296 {ECO:0000313|EMBL:ABB76194.1};
RN [1] {ECO:0000313|EMBL:ABB76194.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3IJ {ECO:0000313|EMBL:ABB76194.1};
RX PubMed=16292000; DOI=10.1093/molbev/msj062;
RA Wheat C.W., Watt W.B., Pollock D.D., Schulte P.M.;
RT "From DNA to fitness differences: sequences and structures of adaptive
RT variants of Colias phosphoglucose isomerase (PGI).";
RL Mol. Biol. Evol. 23:499-512(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|RuleBase:RU000612}.
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DR EMBL; DQ205069; ABB76194.1; -; mRNA.
DR UniPathway; UPA00109; UER00181.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 2: Evidence at transcript level;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABB76194.1"
FT NON_TER 486
FT /evidence="ECO:0000313|EMBL:ABB76194.1"
SQ SEQUENCE 486 AA; 54082 MW; CE48C309116839D8 CRC64;
KVNLKQDPAY QKLQEYYNNN ADKINILQLF QQDADRFNKY SLRIPTPNDG EILLDYSKNR
IDDTTFSLLL NLAKSRNVEK ARDAMFAGEK INFTEDRAVL HVALRNRQNR PIMVNGKDVT
PDVNAVLAHM KEFSTQVISG AWKGYTGKXI TDVINIGIGG SDLGPLMVTE ALKPYANHLK
VHFVSNIDGT HLAEVLKRLN PETALFIIAS KTFTTQETIT NATSAKTWFL EAAKDPAAVS
KHFVALSTNG EKVTAFGIDP KNMFGFWDWV GGRYSLWSAI GLSISLYIGF ENFEKLLDGA
NFMDNHFCTA PLEKNAPVIL ALLGVWYGNF YGAETHALLP YDQYLHRFAA YFQQGDMESN
GKYVTRSGAT VXYSTGPVVW GEPGTNGQHA FYQLVHQGTR LIPCDFLAPA QTHNPIANGA
HHKILLANFL AQTEALMKGK TDAEAKAELE KSGMXPEAIX KILPHKVFKG NRPTNSIVVK
KFTPFT
//
