ID   Q2QBE6_CHV16            Unreviewed;      1242 AA.
AC   Q2QBE6;
DT   24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   24-JAN-2006, sequence version 1.
DT   06-MAR-2013, entry version 49.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=UL30;
OS   Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=340907;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OH   NCBI_TaxID=285350; Macaca leonina (Northern pig-tailed macaque).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH   NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=X313;
RA   Tyler S., Severini A.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=X313;
RX   PubMed=16414998; DOI=10.1128/JVI.80.3.1214-1221.2006;
RA   Tyler S.D., Severini A.;
RT   "The complete genome sequence of herpesvirus papio 2 (Cercopithecine
RT   herpesvirus 16) shows evidence of recombination events among various
RT   progenitor herpesviruses.";
RL   J. Virol. 80:1214-1221(2006).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
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DR   EMBL; DQ149153; ABA29284.1; -; Genomic_DNA.
DR   RefSeq; YP_443877.1; NC_007653.1.
DR   GeneID; 3850215; -.
DR   ProtClustDB; CLSP2511265; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0004523; F:ribonuclease H activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1600.10; -; 2.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR023211; DNA_pol_palm_dom.
DR   InterPro; IPR021639; DNAPolymera_Pol_C.
DR   InterPro; IPR012337; RNaseH-like_dom.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF11590; DNAPolymera_Pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; RNaseH_fold; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase.
SQ   SEQUENCE   1242 AA;  135927 MW;  148B6E7C64A4A958 CRC64;
     MGPVGRGGPG AGAAARAAAA GFFGPPAGRG SAPPPRPREN FYNPYLAAGR RSGAAGRGAQ
     PAPHSYCSEC DEFRFVAPRA LDEDAAPEMR VGVHDGRLRR APRVYCGGEE RDVLDFGRDA
     FWPRRARLWA GVDRAPAEAA PPVDLFHVYD IVENVEHAQH GGCAGRAHGR FLDAITPSGT
     VVTLLGLTPE GRRVAVHVYG TRQYFYMNRA EVDRRLGCRA PRDLCERMAT ALRESPGGSF
     RNISADHFEV DVVDRADVYY YETPRVPYYR VYARNGRALA YLCDNFCPGI RKYEGGVDAT
     TRFVLDNPGF VTFGWYRLGP GRDGAPPHPR PAEAFVTSSD VEIDCTADNL AVERERGDLP
     GYKLMCFDIE CKAGGEDEAA FPVAANAEDL VIQISCLLYD LAAARLEHIL LFSLGSCDLP
     EAFVADLGAR GLPAPTVLEF DSEFEMLLAF VTFVKQYGPE FATGYNIINF DWPFLIAKLT
     DVYKVPLDGY GRMNRRGVFR VWDIGQSHFQ KRSKIKMNGV VNIDMYGIVC DKVKLSSYKL
     NAVAEAVLKD KKKDLSYRDI PRYYAAGPAQ RGVIGEYCVQ DSLLVGQLFF KFLPHLELSA
     VARLAGITLT RTIYDGQQIR VYTCLLRLAG QKGFLLPDNP GRFAGAAAAP AGGDGGREEE
     DAAGAEEDGG DAGAGAGEGG GDEDAFGGGA EPAAREGGAG RHVGYQGAKV LDPASGFHVD
     PVVVFDFASL YPSIIQAHNL CFSTLSLSAD AVAGLEPERD YLAIEVGGRR LFFVKAHVRE
     SLLSILLRDW LAMRKQIRSR IPHSAPEEAV LLDKQQAAIK VVCNSVYGFT GVQHGLLPCL
     HVAATVTTIG RDMLLATREY VHARWTTFDR LEADFPEAAT MRAPGPFSMR IIYGDTDSIF
     VLSRGLTAEG LTAMGDRMAA HISRALFPPP IKLECEKTFT KLLLIAKKKY IGVICGGKML
     IKGVDLVRKN NCAFINRTSR ALVDLLFYDD AVSAAAAALA ARPPEEWLAH PLPEGLDAFG
     RVLVDAHRRI TDPDRDVRDF VLTSELSRHP RAYANKRLPH LTVYYKLLAR RDQVPSIKDR
     IPYVIVAQTR EVEETVARID ALRELDAAPP APPEPPPPPA SAPAPPKRPR GRQPGDPEPK
     RRRLLVSELA EDPAHAVAHR VPLNTDYYFS HLLGAACVTF KALFGNNAKI TENLLKRFIP
     EVWHPEEETA VRLRAAGFRA AGAGATEAET RRRLRTAFDT LA
//