ID   Q2QBG8_CHV16            Unreviewed;       892 AA.
AC   Q2QBG8;
DT   24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   24-JAN-2006, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=Replication origin-binding protein {ECO:0000256|ARBA:ARBA00014069};
DE   AltName: Full=OriBP {ECO:0000256|ARBA:ARBA00031715};
GN   Name=UL9 {ECO:0000313|EMBL:ABA29262.1};
OS   Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC   Simplexvirus papiinealpha2.
OX   NCBI_TaxID=340907 {ECO:0000313|EMBL:ABA29262.1, ECO:0000313|Proteomes:UP000132309};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OH   NCBI_TaxID=90387; Macaca leonina (Northern pig-tailed macaque) (Macaca nemestrina leonina).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH   NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque).
RN   [1] {ECO:0000313|EMBL:ABA29262.1, ECO:0000313|Proteomes:UP000132309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=X313 {ECO:0000313|EMBL:ABA29262.1};
RX   PubMed=16414998; DOI=10.1128/JVI.80.3.1214-1221.2006;
RA   Tyler S.D., Severini A.;
RT   "The complete genome sequence of herpesvirus papio 2 (Cercopithecine
RT   herpesvirus 16) shows evidence of recombination events among various
RT   progenitor herpesviruses.";
RL   J. Virol. 80:1214-1221(2006).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication. {ECO:0000256|ARBA:ARBA00025279}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family.
CC       {ECO:0000256|ARBA:ARBA00007195}.
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DR   EMBL; DQ149153; ABA29262.1; -; Genomic_DNA.
DR   RefSeq; YP_443855.1; NC_007653.1.
DR   GeneID; 3850168; -.
DR   KEGG; vg:3850168; -.
DR   Proteomes; UP000132309; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          94..259
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          291..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  97760 MW;  31C1461ABD87DE91 CRC64;
     MSSPRRQSTE TTNAPTWTHQ AHHAARETGS PPAGAAEALL DDLPIAEGDL ARYASSVSLA
     RMLYGGDLAE WVPRVHPRVT IERQAGGPVS FPDAGAPTSR CVTVVRAPMG SGKTTALLRW
     LREAIHSPDT SVLVVSCRRS FTQTLAARFA ASGLEDFVTY FSSTNYIMDD RPFHRLIVQV
     ESLHRVGPNL LNNYDVLVLD EVMSTVAQLY SPTMQQLCRV DALLMRLLRA CPRIIAMDAT
     ANAQLVDFLC GLRGERNVHV VVGEYATPGF SERRCLFLQR LGPEVLQEAL RTEGGGAPPG
     ERAPPGCSPG GAAPQEARPP EAGTFFGELE TRLAAGDNVC LFSSTVSFAE IAARFCRRFT
     DRVLLLHSLT PPGDVATWGE YRVVIYTTVV TVGLSFDPVH FDSMFAYVKP MNYGPDMVSV
     YQSLGRVRTL RRGELLVYMD GAGARSEPVF TPMLLNHVVG ARGRWPAQFS EVTGLLCRRF
     KGRCDASARG EAAAARGSRV YARFRYKHYF ERCTLACLAD SLNILHTLLT LNCVRARFWG
     HEAAPSPRDF CRFLRGAHLD ALRAQRPLRE LRGGDPGVSL QARAADTEEV GFFVEKYLRP
     DVGPEEIVAL MRGLGGPVGR TRFAHLVLLE ACLRVPTALH SSAVFRRLYD HYATGVVPTV
     GPAGEIEMVA LQPTLNVAPV WELFRLCGGL AQRLRWDAAA GGSGGNFSAR DVLALMRPHY
     ERYLQLLFEV GHCNVTDGSL LSEEAVRRVT DALSGRPPGG AVGEAEHALM LFRILWSELF
     GVQTVKSTQT FPGVGRVKNL TKDAIIGLLD AHRIDRSACR THRQLYALLM AHKRDFAEAR
     FRLRAPAWGR CLRTRATGGA QPGPDLVLEA ALSELPAEAW PTTHGALDFS TL
//