ID Q2QIN4_9HIV1 Unreviewed; 195 AA.
AC Q2QIN4;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAZ31914.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAZ31914.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAZ31914.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAZ31914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BR04RS198 {ECO:0000313|EMBL:AAZ31914.1};
RX PubMed=16332398; DOI=10.1016/j.virusres.2005.10.004;
RA Rodrigues R., Scherer L.C., Oliveira C.M., Franco H.M., Sperhacke R.D.,
RA Ferreira J.L., Castro S.M., Stella I.M., Brigido L.F.;
RT "Low prevalence of primary antiretroviral resistance mutations and
RT predominance of HIV-1 clade C at polymerase gene in newly diagnosed
RT individuals from south Brazil.";
RL Virus Res. 116:201-207(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
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DR EMBL; DQ070665; AAZ31914.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:AAZ31914.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..195
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ31914.1"
FT NON_TER 195
FT /evidence="ECO:0000313|EMBL:AAZ31914.1"
SQ SEQUENCE 195 AA; 22661 MW; BEC4C10292DBD90A CRC64;
IKALTAICEE MEKEGKITKI GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKRTQDFWEV
QLGIPHPAGL KKKKSVTVLD VGDAYFSVPL DKEFRKYTAF TIPSVNNETP GIRYQYNVLP
QGWKGSPAIF QCSMTKILEP FRKQNSNIII YQYMDDLYVG SDLEIGQHRA KIEELRQHLL
KWGFTTPDKK HQKEP
//