ID Q2TBW4_BOVIN Unreviewed; 600 AA.
AC Q2TBW4;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Polycystic kidney disease 2-like 2 {ECO:0000313|EMBL:AAI09573.1};
DE SubName: Full=Polycystin 2 like 2, transient receptor potential cation channel {ECO:0000313|Ensembl:ENSBTAP00000010236.4};
GN Name=PKD2L2 {ECO:0000313|EMBL:AAI09573.1,
GN ECO:0000313|Ensembl:ENSBTAP00000010236.4,
GN ECO:0000313|VGNC:VGNC:32937};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI09573.1};
RN [1] {ECO:0000313|EMBL:AAI09573.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI09573.1};
RC TISSUE=Liver {ECO:0000313|EMBL:AAI09573.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000010236.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000010236.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000010236.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000010236.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR EMBL; BC109572; AAI09573.1; -; mRNA.
DR RefSeq; NP_001033641.1; NM_001038552.2.
DR RefSeq; XP_010805607.1; XM_010807305.2.
DR STRING; 9913.ENSBTAP00000010236; -.
DR PaxDb; 9913-ENSBTAP00000010236; -.
DR Ensembl; ENSBTAT00000010236.5; ENSBTAP00000010236.4; ENSBTAG00000007785.5.
DR GeneID; 521683; -.
DR KEGG; bta:521683; -.
DR CTD; 27039; -.
DR VEuPathDB; HostDB:ENSBTAG00000007785; -.
DR VGNC; VGNC:32937; PKD2L2.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000161122; -.
DR HOGENOM; CLU_012097_1_2_1; -.
DR OMA; VNTDMYY; -.
DR TreeFam; TF316484; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000007785; Expressed in spermatid and 81 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 251..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..246
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 247..471
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT DISULFID 115..128
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 600 AA; 71610 MW; EEF182AA70173346 CRC64;
MAEASRWHLG GTPKHKLHYR EDVEIRTTLQ ELLLYSIFLI NLCISGEERT NFKSIRSITD
FWKFMEGPLL DGLYWDSWYN NENLYDLKNS SRIYYENILL GLPRVRQLKV RNGTCKVHSF
FRSLMDECYD KYTSKNEDTA DFGLKQHTEW KYSSPRTNSP WHWGFVGVYQ NGGYIFTLSK
SKSETLNKFI NLRMNSWITR GTRVIFIDFS VYNANVNLFC IIRLVAEFPA TGGILTSWQF
YSVKLLRYVS FYDYFIASCE IIFCIFIIVF TIQEIKKLKE FKFAYFKSIW NWLELLLLVL
CFSTVFFSLY SNMQIYRMIG RLLRNTEKYS DFYFLAYWHI YYNNIIAITI FFAWIKIFKF
ISFNKTMSQL SSTLSRCIKD IIGFAIMFFI IFFAYAQLGF LVFGSQVDDF STFQNAIFTQ
FRIVLGDFNF AGIQQANRIL GPIYFITFIF FVFFVLLNMF LAIINDTYSE VKADYSIGRR
PDFQLGKMIK KSYNNALEKL KLKKPETDED KKRMENKDLA EKARREGFDE KEIQSAEQMK
KWKERLEKKY YSTEIQDDYQ TVTQQEFRDL FLYAVELEKE LHYVSLKLNR VMRKVSALQY
//
