ID Q2U319_ASPOR Unreviewed; 390 AA.
AC Q2U319;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN ORFNames=AO090038000229 {ECO:0000313|EMBL:BAE64046.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE64046.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE64046.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AP007169; BAE64046.1; -; Genomic_DNA.
DR RefSeq; XP_001825179.1; XM_001825127.1.
DR AlphaFoldDB; Q2U319; -.
DR STRING; 510516.Q2U319; -.
DR MEROPS; A01.018; -.
DR EnsemblFungi; BAE64046; BAE64046; AO090038000229.
DR GeneID; 5997274; -.
DR KEGG; aor:AO090038000229; -.
DR VEuPathDB; FungiDB:AO090038000229; -.
DR HOGENOM; CLU_013253_3_4_1; -.
DR OMA; KMPSIRD; -.
DR OrthoDB; 2253145at2759; -.
DR Proteomes; UP000006564; Chromosome 6.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF89; SACCHAROPEPSIN; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..390
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004216938"
FT DOMAIN 77..384
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT DISULFID 108..113
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 310..343
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 390 AA; 43362 MW; 5AC6D22849F5A5EB CRC64;
MKPILLAVPL LLSYTAAEIH RVPLEKELLV FGSDDDDTRT SSQRYIGSNT HQKALQDHGP
DILGHDIPVK NHRNTQYFST IRIGTPPQKF KVVLDTGSAN LWVPSSKCKT ISCKKHKKYK
SALSDTYHNN GSEFEIYYGS GGMTGHVSED IFTIGDLKVQ EQLFGEATKV SGFSNVKADG
ILGLGFASIS VNSIPPPFYN MLDQNLLDEP VFAFYLSDTY KGRTSEITFG GVDEQHYSGE
IVKIPLRRKA YWEVEFSGLF FGDHFADVED TGAILNTGSS LIGLPSGLFE TVNKEIGATR
DYQGRYILDC DKRSFMPSLT FVLGEYNFTI DPKDYSLQEQ NFCMSALVPM DFPGPTGPLV
VLGDAFLRRW YSVYDFGNGA IGLAQAKRKE
//
