ID Q2UD95_ASPOR Unreviewed; 845 AA.
AC Q2UD95;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090012000265 {ECO:0000313|EMBL:BAE60470.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE60470.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE60470.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037882}.
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DR EMBL; AP007161; BAE60470.1; -; Genomic_DNA.
DR RefSeq; XP_001727309.1; XM_001727257.2.
DR AlphaFoldDB; Q2UD95; -.
DR STRING; 510516.Q2UD95; -.
DR EnsemblFungi; BAE60470; BAE60470; AO090012000265.
DR GeneID; 5987783; -.
DR KEGG; aor:AO090012000265; -.
DR VEuPathDB; FungiDB:AO090012000265; -.
DR HOGENOM; CLU_006921_0_1_1; -.
DR OMA; FKHWHPT; -.
DR OrthoDB; 1416at2759; -.
DR Proteomes; UP000006564; Chromosome 4.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024775; DinB-like.
DR InterPro; IPR019257; MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR NCBIfam; TIGR03439; methyl_EasF; 1.
DR PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR Pfam; PF12867; DinB_2; 1.
DR Pfam; PF03781; FGE-sulfatase; 2.
DR Pfam; PF10017; Methyltransf_33; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 27..331
FT /note="Histidine-specific methyltransferase SAM-dependent"
FT /evidence="ECO:0000259|Pfam:PF10017"
FT DOMAIN 362..492
FT /note="DinB-like"
FT /evidence="ECO:0000259|Pfam:PF12867"
FT DOMAIN 554..671
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT DOMAIN 769..843
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
SQ SEQUENCE 845 AA; 95796 MW; CBF7D0A3678F1BB5 CRC64;
MSPLALSPKT VDIVNIFQND VEFSLVNEIH KGISPPAGVR KSMPTMLLYD ANGLKLFEKI
TYVKEYYLTN AEIEVLETNS RRIVERIPDN AQLLELGSGN LRKIEILLRE FERVGKRVDY
YALDLSLSEL QRTFAEVSID DYTHVGLHGL HGTYDDAVTW LNSPENRKRP TVIMSMGSSL
GNFDRPGAAK FLSQYASLLG PSDMMIIGLD GCKDPGKVYR AYNDSEGVTR QFYENGLVHA
NVVLGYEAFK PDEWEVVTDY DAVEGRHWAA YSPRRDVTIN GVLLKKGEKL FFEEAYKYGP
EERDQLWRDA KLLQSTEVGN GSDDYHLHLL TSAALNLPTS PSQYAAHPIP SFEEWQSLWT
AWDNATKAMV PREELLSKPI KLRNSLIFYL GHIPTFLDIH LTRALRGKLT EPKSYKLIFE
RGIDPDVDDP QKCHSHSEIP DEWPALDDIL DYQERVRSRV RSIYQIEGLA ENRILGEALW
IGFEHEVMHL ETFLYMLIQS ERILPPPATE RPDFKKLYQD ARRSMKTNEW FSVPEQTLTI
GLDGADTNDV PPTTYGWDNE KPARTVTVPA FEAQGRPITN GEYAKYLQAN QSRRRPASWV
LTHSDENYPI PMAVNGSSVG ATQDFMSNFA VRTVFGPVPL EFAQDWPVMA SYDELAEYAE
WVGCRIPTFE ETRSIYLHSA LLKERGGVNH NGEPNGHSVN GYLNGMNGNS YSKINPGKPR
TPDHQPVQYP SRDALPVFLD LDGLNVGFKH WHPTPVIQNG DRLAGQGELG GAWEWTSTPL
APHDGFKAME IYPGYTSDFF DGKHNIILGG SWATHPRVAG RTTFVNWYQH NYPYTWAGAR
LVRDL
//
