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Database: UniProt
Entry: Q2UI87
LinkDB: Q2UI87
Original site: Q2UI87 
ID   AGALD_ASPOR             Reviewed;         657 AA.
AC   Q2UI87;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   19-FEB-2014, entry version 41.
DE   RecName: Full=Probable alpha-galactosidase D;
DE            EC=3.2.1.22;
DE   AltName: Full=Melibiase D;
DE   Flags: Precursor;
GN   Name=aglD; ORFNames=AO090023000151;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G.,
RA   Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K.,
RA   Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W.,
RA   Galagan J.E., Nierman W.C., Yu J., Archer D.B., Bennett J.W.,
RA   Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H.,
RA   Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R.,
RA   Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N.,
RA   Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I.,
RA   Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y.,
RA   Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y.,
RA   Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K.,
RA   Kuhara S., Ogasawara N., Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Hydrolyzes a variety of simple alpha-D-galactoside as
CC       well as more complex molecules such as oligosaccharides and
CC       polysaccharides (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of terminal, non-reducing alpha-D-
CC       galactose residues in alpha-D-galactosides, including galactose
CC       oligosaccharides, galactomannans and galactolipids.
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 27 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE58728.1; Type=Erroneous gene model prediction;
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DR   EMBL; AP007157; BAE58728.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001820730.2; XM_001820678.2.
DR   ProteinModelPortal; Q2UI87; -.
DR   GeneID; 5992732; -.
DR   KEGG; aor:AOR_1_260144; -.
DR   eggNOG; NOG68897; -.
DR   HOGENOM; HOG000161224; -.
DR   OrthoDB; EOG7CNZQQ; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052692; F:raffinose alpha-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013780; Glyco_hydro_13_b.
DR   InterPro; IPR002241; Glyco_hydro_27.
DR   InterPro; IPR000111; Glyco_hydro_GHD.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF02065; Melibiase; 1.
DR   PRINTS; PR00740; GLHYDRLASE27.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Disulfide bond;
KW   Glycoprotein; Glycosidase; Hydrolase; Polysaccharide degradation;
KW   Secreted; Signal.
FT   SIGNAL        1     16       Potential.
FT   CHAIN        17    657       Probable alpha-galactosidase D.
FT                                /FTId=PRO_0000395073.
FT   REGION      200    204       Substrate binding (By similarity).
FT   ACT_SITE    155    155       Nucleophile (By similarity).
FT   ACT_SITE    222    222       Proton donor (By similarity).
FT   CARBOHYD     47     47       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     91     91       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    182    182       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    191    191       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    291    291       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    438    438       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    460    460       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    505    505       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    539    539       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    543    543       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    582    582       N-linked (GlcNAc...) (Potential).
FT   DISULFID    124    157       By similarity.
SQ   SEQUENCE   657 AA;  71140 MW;  50917D2103A5E8DF CRC64;
     MLPKIFYLSL LPAALGHPHL QPRLDNGLAR TPQMGWNTYN HYSCSPNETI VRSNAQALVD
     LGLASLGYRY VTTDCGWTVA DRLSDGSLTW NETLFPKGFP ALGKYLHDLD LLFGVYQDSG
     IKLCGSPPDN VGSLYHEDQD ARTFASWEVD SLKYDNCYSD AATGYPNVNY EPSTSPQPRF
     ANMSRALAAQ NRSMVFQVCE WGIDFPARWA PALGHSWRIG NDIIPHWRAI YRTLNQAVPQ
     TSFAGPGQWP DLDMLFVGND ILSIPEEQTH FSLWAILKSP LTIGAALKDD NTSINDESLQ
     ILKQEEVIGY NQDSLGVSAS LRRRWTEEGY EVWSGPLSGG RTVAALINWK DEARELTLDL
     PDIGLQFAGT VKNIWDGTTA QNVKTSYTAK VQSHGTILLE LQDTTASGQY PTDTFATSTD
     SSTTFESIYG VTTSFRYNIT VKLSEASSSG DVNIQSTASN KTITAQVSAS GTEASAQIPL
     LAGSSNSITI VSPQSVDAIT ITPPNGTYFP NTAFTTTGDA DTVSCGAGYC QPVGSKIGNI
     STNGTARAVI PATAGTKYLA IDYINNDVAF DSAWDWGSNS RNLTVSVNGN KPVRIEVPLS
     GQHSELFGPG KGWWDTATIG VLTEGWKDGD NDVVIGNEGG ESGFTSYGPD FVGLRVL
//
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