ID Q2UK11_ASPOR Unreviewed; 456 AA.
AC Q2UK11;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=UPF0020 domain-containing protein {ECO:0000259|Pfam:PF01170};
GN ORFNames=AO090003000995 {ECO:0000313|EMBL:BAE58104.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE58104.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE58104.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP007155; BAE58104.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UK11; -.
DR STRING; 510516.Q2UK11; -.
DR EnsemblFungi; BAE58104; BAE58104; AO090003000995.
DR HOGENOM; CLU_029646_3_0_1; -.
DR OMA; QAFNKWS; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0043528; C:tRNA (m2G10) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0030488; P:tRNA methylation; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 192..309
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 456 AA; 51974 MW; 6A202BE71B166609 CRC64;
MEYVIRFAQV HETFRRPEIE SLAALAGIDL EILYYDQFSP YCVIRVPTEA DARTLIARSI
LAKDIFELWG QGTNYEEVHA DVRRRTQHRW DEFKNVSFRF TIDSFCGKRK IEAKRAIIQS
FSYVGFDGPI RMKNPDEDFW VLEDFVSDVE VATRTPGNTH AYSEALEPRK IYLGRWIANS
SRNIVSKYDL KKRRYISTTS MDAELSLVTA NMAHAAPGRL FYDPFVGTGS FCVAAAHFGA
LTCGSDIDPR SFKGREKNDK EPMGLFTNFQ QYGIESKFMD AFSSDLTNTP LLNRQFLDGI
VCDPPYGVRE GLRVLGTRDG SGREEVIIDG VPAHYRPGYI PPKKPYGFEA MQNDILAFAS
RTLVTDGRLC MWMPTSIDED VELLIPMHPH LEVVSVSVQP FNQWSRRLIT YRRLPEGQVS
DISKARQKGD SEGISADDLN AFRRKVCHQY TLSYAP
//
