ID Q2UNG5_ASPOR Unreviewed; 690 AA.
AC Q2UNG5;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Acetoacetyl-CoA synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090001000376 {ECO:0000313|EMBL:BAE56900.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE56900.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE56900.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP007154; BAE56900.1; -; Genomic_DNA.
DR RefSeq; XP_001818902.1; XM_001818850.2.
DR AlphaFoldDB; Q2UNG5; -.
DR STRING; 510516.Q2UNG5; -.
DR EnsemblFungi; BAE56900; BAE56900; AO090001000376.
DR GeneID; 5990873; -.
DR KEGG; aor:AO090001000376; -.
DR VEuPathDB; FungiDB:AO090001000376; -.
DR HOGENOM; CLU_000022_3_3_1; -.
DR OMA; MPNTWQT; -.
DR OrthoDB; 45466at2759; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564}.
FT DOMAIN 42..99
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 110..501
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 690 AA; 76205 MW; 255DBDA3730529C4 CRC64;
MSSNGVPTGS KELWRHSSPQ DTQIYDFMMK LNAEHNLSLK SYNDLWRWSI SKPALFWERI
WHYTAIKSHK PYDRVLESDG DLFPRPNFFE GSRLNFAENL LYPASALDEN EVAIIAATES
EREYVSWKEL RERVRQCASS LKEAGLQSGD RVAGFLGNHT NTVVAMLATS SIGAFWTGVS
PDTGVHAVLE RLKQIEPKIL FADNASLYNG KVHGAEAKIR QIVPGLPNLE LLVVFETIKS
HQINLEELSP AQGKVSTYES FLSAASDPSA PLEFASLEPG HPVYILYSSG TTGAPKPIVH
GSLGTLLQHK KEHMLHCDIR PGDRLFYFTT VTWMMWHWLV SGLASGATIV LYDGSPFRPF
DSEGGNGEMA MPRLIDELKI THFGTSAKYL SILEQASLNP RKHPHRPVTL QTLRAIFSTG
SPLAPSTFEY VYSSFHPDIM LGSITGGTDI LSLFCSCCPI LPVYKGEIQC RSLAMAVSVY
DYAGNDISAS GEPGDLVCTK PFPAQPVMFW PPGAVGEEKY RKSYFDIFGP SVWHHGDFVR
LDPQTGGVVM LGRSDGVLKP AGVRFGSAEI YNILLKHFAE EVEDSLCIGR RRDGIDTDET
VVLFVKLASQ EKTIPQELAA RIQATIRKEL SPRHVPGIVD ACPEIPVTSN GKKVENAVKQ
ILCGLNIKIG ASVANASCLD WYRAWATANS
//
