ID Q2UPN3_ASPOR Unreviewed; 715 AA.
AC Q2UPN3;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=AMP-dependent synthetase and ligase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090005001575 {ECO:0000313|EMBL:BAE56482.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE56482.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE56482.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; AP007151; BAE56482.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UPN3; -.
DR STRING; 510516.Q2UPN3; -.
DR EnsemblFungi; BAE56482; BAE56482; AO090005001575.
DR HOGENOM; CLU_000022_46_3_1; -.
DR OMA; VWRQFLD; -.
DR OrthoDB; 1650656at2759; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR GO; GO:0005777; C:peroxisome; IEA:EnsemblFungi.
DR GO; GO:0005324; F:long-chain fatty acid transporter activity; IEA:EnsemblFungi.
DR GO; GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:EnsemblFungi.
DR GO; GO:0044539; P:long-chain fatty acid import into cell; IEA:EnsemblFungi.
DR GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR GO; GO:0000038; P:very long-chain fatty acid metabolic process; IEA:EnsemblFungi.
DR CDD; cd05937; FATP_chFAT1_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107:SF15; FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A; 1.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 116..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..446
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 518..606
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 715 AA; 79563 MW; C56D2B86F1BD2B92 CRC64;
MPLPLPDIPL SIATPAVATT LAYLNAKYSL FYDVTLIGGL IKSIFKSRLA ERRDHLNLFY
VLEQHALAPA TKDNQFIVYN GRAWTFHETY VMALRYGAWL KKAHGIKPKE IVAMDFMNSS
TFIFLLLGLW SIGAVPAFIN YNLSGKPLTH CVRTSTARLL VVDEEIRQQF TPEQMETLGS
PEFREGGGSV DVVFLTPEVE SQIMQMEATR EDDSVRNGPA LRDLALLIYT SGTTGLPKPA
IVSWRKCWSG GTFVAHWLGL AKNDRFFTCM PLYHSSASIL GFVTCLMSGS TLIIGRKFSA
RNFWREAREN QATIVQYVGE TLRYLMAVPP EIDAVTGEDL DKKHNVRAVF GNGLRPDIWG
RFKERFNVPT IAEFYSATEG TSGSWNLSSN DFTAGAIGRN GSLSRLILGG GLAVVQVDHE
SQQPWRDPKT GFCKEVPRGE PGELLYAINA ADPVETFQGY FKNSKATESK IVRDVLRKGD
AYFRTGDMVR WDAEGRWYFN DRLGDTFRWK SENVSTSEVA EVLGAHPDVH EANVYGVTLP
NHDGRAGCAA IILQQQHQAT DPSVLIPPTP ETLSSLAAHA LKNLPRFAVP LFLRLAPEMQ
GTGNNKQQKH VLRTEGVDPS LVSTSDKLYW LQGDKLLKEA ASRLPGELPS IELEKVHTKS
GDEPSQNRYY NYTNRNSCTA SGYCIDDLAS ENAVHHAISQ HDTWLNTRPN TAIPL
//
