ID Q2UXE3_STAAU Unreviewed; 392 AA.
AC Q2UXE3;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 13-SEP-2023, entry version 54.
DE SubName: Full=Clumping factor A {ECO:0000313|EMBL:CAJ27539.1};
DE Flags: Fragment;
GN Name=clfA {ECO:0000313|EMBL:CAJ27539.1};
OS Staphylococcus aureus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:CAJ27539.1};
RN [1] {ECO:0000313|EMBL:CAJ27539.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=01-1111 {ECO:0000313|EMBL:CAJ27545.1}, 01-1222
RC {ECO:0000313|EMBL:CAJ27546.1}, 01-1279 {ECO:0000313|EMBL:CAJ27547.1},
RC 1150-93 {ECO:0000313|EMBL:CAJ27557.1}, 45030564
RC {ECO:0000313|EMBL:CAJ27559.1}, AI {ECO:0000313|EMBL:CAJ27542.1}, B2
RC {ECO:0000313|EMBL:CAJ27544.1}, BI {ECO:0000313|EMBL:CAJ27543.1}, GE79
RC {ECO:0000313|EMBL:CAJ27565.1}, H13717 {ECO:0000313|EMBL:CAJ27577.1},
RC H6606 {ECO:0000313|EMBL:CAJ27538.1}, and IH76167
RC {ECO:0000313|EMBL:CAJ27539.1};
RX PubMed=16352833; DOI=10.1128/JB.188.1.169-178.2006;
RA Kuhn G., Francioli P., Blanc D.S.;
RT "Evidence for clonal evolution among highly polymorphic genes in
RT methicillin-resistant Staphylococcus aureus.";
RL J. Bacteriol. 188:169-178(2006).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
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DR EMBL; AM075848; CAJ27538.1; -; Genomic_DNA.
DR EMBL; AM075849; CAJ27539.1; -; Genomic_DNA.
DR EMBL; AM075852; CAJ27542.1; -; Genomic_DNA.
DR EMBL; AM075853; CAJ27543.1; -; Genomic_DNA.
DR EMBL; AM075854; CAJ27544.1; -; Genomic_DNA.
DR EMBL; AM075855; CAJ27545.1; -; Genomic_DNA.
DR EMBL; AM075856; CAJ27546.1; -; Genomic_DNA.
DR EMBL; AM075857; CAJ27547.1; -; Genomic_DNA.
DR EMBL; AM075867; CAJ27557.1; -; Genomic_DNA.
DR EMBL; AM075869; CAJ27559.1; -; Genomic_DNA.
DR EMBL; AM075875; CAJ27565.1; -; Genomic_DNA.
DR EMBL; AM075887; CAJ27577.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UXE3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1280; -; 1.
DR Gene3D; 2.60.40.1290; -; 1.
DR InterPro; IPR011266; Adhesin_Fg-bd_dom_2.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR041171; SDR_Ig.
DR Pfam; PF17961; Big_8; 1.
DR Pfam; PF10425; SdrG_C_C; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 108..206
FT /note="SDR-like Ig"
FT /evidence="ECO:0000259|Pfam:PF17961"
FT DOMAIN 232..383
FT /note="Fibrinogen-binding"
FT /evidence="ECO:0000259|Pfam:PF10425"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ27539.1"
FT NON_TER 392
FT /evidence="ECO:0000313|EMBL:CAJ27539.1"
SQ SEQUENCE 392 AA; 42181 MW; EA61C8E088BD109E CRC64;
NQTSNETTSN DTNTVSSVNS PQNSTNAENV STTQDTSTEA KPSNNESAPQ STDASNKDVV
NQAVNTSAPR MRAFSLAAVA ADAPAAGTDI TNQLTNVTVG IDSGDTVYPH QAGYVKLNYG
FSVPNSAVQG DTFKITVPKE LNLNGVTSTA KVPPIMAGDQ VLANGVIDSD GNVIYTFTDY
VNTKDDVKAT LTVPAYIDPE YVTHTGNVTL ATGIGNTTAN KTVLVDYEKY GKFYNLSIKG
TIDQIDKTNN TYRQTIYVNP SGDNVIAPVL TGNLKPNTES NALIDQQNTS IKVYKVDNAA
DLSESYFVNP ENFEDVTNSV NITFPNPNQY KVEFNTPDDQ ITTPYIVVVN GHIDPNSKGD
LALRSTLYGY NSNIIWRSMS WDNEVAFNNG SG
//
