ID Q2VB25_9TELE Unreviewed; 799 AA.
AC Q2VB25;
DT 10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Sodium channel 6 {ECO:0000313|EMBL:ABB84813.1};
DE Flags: Fragment;
OS Gnathonemus petersii (elephantnose fish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Gnathonemus.
OX NCBI_TaxID=42645 {ECO:0000313|EMBL:ABB84813.1};
RN [1] {ECO:0000313|EMBL:ABB84813.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16830092; DOI=10.1007/s00239-005-0287-9;
RA Novak A.E., Jost M.C., Lu Y., Taylor A.D., Zakon H.H., Ribera A.B.;
RT "Gene duplications and evolution of vertebrate voltage-gated sodium
RT channels.";
RL J. Mol. Evol. 63:208-221(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ275142; ABB84813.1; -; mRNA.
DR AlphaFoldDB; Q2VB25; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000313|EMBL:ABB84813.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..203
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 211..415
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 420..693
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 741..796
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 315..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABB84813.1"
FT NON_TER 799
FT /evidence="ECO:0000313|EMBL:ABB84813.1"
SQ SEQUENCE 799 AA; 91052 MW; BB5B19C57C51770D CRC64;
FEHVLSVGNL VFSGIFAGEM VLKIIAMDPY YYFQVGWNVF DSIIVTMSMV EMVLADVEGL
SVLRSFRLLR VFKLAKSWPT LNMLLTIIGN SVGALGNLTV VLAIIVFIFA VVGMQLFAKN
YKDCVCKIAE DCELPRWHMH DFFHSFLIVF RILCGEWIET MWDCMEVANR NMCLVLFLMV
MIIGNLVVLN LFLALLLSSF SGDNLQMADD DGELNNLQLS ALRITRAIDW VKAYVRGLIW
KILGKQPKED GVLEDGEGEN HSKEAFNMNN ITRQEPKTDF RVLDGLSHWA DDVHPSGFLL
SSDFTFTVPI AQEESDLEML DTDGEDFSTD EELGEDENPG SKKRFGAPDG VSECSTVDYV
PPPPPPDPDE VEEPEPVEPE ACYTDNCLRR CPCLVLDTSE GRGKTWWNLR RTCYTIVEHD
YFESSIIFMI LLSSGALAFE DIYLERRRTI KILLEYADKV FSYVFVIEML LKWVAYGYKV
YFTNAWCWLD FLIVDVSLVS LAASIMGYSE LGPIKSLRTL RALRPLRALS RFEGMRVVVN
ALVGAVPAIF NVMLVCLIFW LIFSIMGVNL FAGTFYHCLN TTTGEMFTID VVNNYSECLA
LMHTNEVRWA NVRVNYDNVG MGYLSLLQVS TFKGWMEIMY AAVDSRKVGQ QPSYEANLYM
YVYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KNKMGGDCFM TEEQKKYYDA MKKLGNKKPA
KPIPRPTGKI PGLVYDFISQ QAFDIFIMVL ICLNMVTMMV EEDDQSEQKT DMLGKINAVF
IVVFSSECLL KMIALRQYF
//
