ID   Q2VCM4_VULCH            Unreviewed;       244 AA.
AC   Q2VCM4;
DT   10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   10-JAN-2006, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=VWF {ECO:0000313|EMBL:ABB48405.1};
OS   Vulpes chama (Cape fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9626 {ECO:0000313|EMBL:ABB48405.1};
RN   [1] {ECO:0000313|EMBL:ABB48405.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=F3 {ECO:0000313|EMBL:ABB48405.1};
RA   Pollinger J.P., Bardeleben C., Koepfli K.-P., Wayne R.K., Lindblad-Toh K.;
RT   "Genome Sequence, Comparative Analysis and Haplotype Structure of the
RT   Domestic Dog.";
RL   Nature 0:0-0(2005).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   EMBL; DQ240812; ABB48405.1; -; Genomic_DNA.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF16164; VWA_N2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          37..213
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          225..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABB48405.1"
FT   NON_TER         244
FT                   /evidence="ECO:0000313|EMBL:ABB48405.1"
SQ   SEQUENCE   244 AA;  27330 MW;  E6494CCFF380719F CRC64;
     GSLVVPPTEG PIGSTTLYVE DTPEPPLHDF HCSRLLDLVF LLDGSSKLSE DEFEVLKVFV
     VGMMEHLHIS QKRIRVAVVE YHDGSHAYIE LKDRKRPSEL RRITSQVKYX GSEVASTSEV
     LKYTLFQIFG RIDRPEASRI ALLLMASQEP LRLARNLVRY VQGLKKKKVI VIPVGIGPHA
     SRKQINLIEK QAPENKAFVL SGVDELEQRR DEIINYLCDL APEAPAPTQH PPMAQVTVGP
     ELLG
//