ID Q2WFL4_9NOCA Unreviewed; 419 AA.
AC Q2WFL4;
DT 10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:BAE53386.1};
OS Smaragdicoccus niigatensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Smaragdicoccus.
OX NCBI_TaxID=359359 {ECO:0000313|EMBL:BAE53386.1};
RN [1] {ECO:0000313|EMBL:BAE53386.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hou_blue {ECO:0000313|EMBL:BAE53386.1};
RA Adachi K., Katsuta A., Matsuda S., Peng X., Misawa N., Shizuri Y.,
RA Kroppenstedt R.M., Yokota A., Kasai H.;
RT "Smaragdicoccus niigatensis gen. nov., sp. nov., a novel member of the
RT suborder Corynebacterineae.";
RL Int. J. Syst. Evol. Microbiol. 57:297-301(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; AB243008; BAE53386.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2WFL4; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 343..419
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAE53386.1"
FT NON_TER 419
FT /evidence="ECO:0000313|EMBL:BAE53386.1"
SQ SEQUENCE 419 AA; 45937 MW; 4B8007AE7AA0B3D9 CRC64;
SDSYAVSGGL HGVGISVVNA LSTKVEVDIN HDGYNWTQTY NYAKPTELVR GKATRATGTT
IRFWADPNIF ETTTYSFDTV ARRLQEMAFL NKGLTIVLTD KRVKEEDVVD EVVSDTAEAP
KGHDEAAADA PVVHKVMTRT YHYPGGLNDF VKHINRTKTP IHTSVVGFSE KGTGHELEIA
MQWNSGYSES VHTFANTINT HEGGTHEEGF RAALTTVVNK YAKDKKLIKE KDGNLSGDDI
REGLAAIVSV KVGEPQFEGQ TKTKLGNTEV KSFVQKACNE HIAHWFEANP ADAKTIINKA
LSSMQARVAA RKARELVRRK SATDIGGLPG KLADCRSNDP SRCELYVVEG DSAGGSAKTG
RDSMFQAILP LRGKIINVEK ARIDRVLKNT EVQAIITALG TGIHDEFDIA KLRYHKIVL
//
