ID Q2WG13_POVBK Unreviewed; 695 AA.
AC Q2WG13;
DT 10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805};
OS BK polyomavirus (BKPyV) (Human polyomavirus 1).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Betapolyomavirus.
OX NCBI_TaxID=1891762 {ECO:0000313|EMBL:BAE53655.1, ECO:0000313|Proteomes:UP000150248};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAE53655.1, ECO:0000313|Proteomes:UP000150248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-3a {ECO:0000313|EMBL:BAE53655.1};
RX PubMed=16432015; DOI=10.1099/vir.0.81368-0;
RA Takasaka T., Goya N., Ishida H., Tanabe K., Toma H., Fujioka T., Omori S.,
RA Zheng H.Y., Chen Q., Nukuzuma S., Kitamura T., Yogo Y.;
RT "Stability of the BK polyomavirus genome in renal-transplant patients
RT without nephropathy.";
RL J. Gen. Virol. 87:303-306(2006).
RN [2] {ECO:0000313|Proteomes:UP000114475, ECO:0000313|Proteomes:UP000133455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=THK-8 {ECO:0000313|EMBL:BAF03036.1}, and TW-3
RC {ECO:0000313|EMBL:BAE96084.1};
RX PubMed=16897259; DOI=10.1007/s00239-005-0092-5;
RA Nishimoto Y., Takasaka T., Hasegawa M., Zheng H.Y., Chen Q., Sugimoto C.,
RA Kitamura T., Yogo Y.;
RT "Evolution of BK virus based on complete genome data.";
RL J. Mol. Evol. 63:341-352(2006).
RN [3] {ECO:0000313|Proteomes:UP000098006, ECO:0000313|Proteomes:UP000127094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPN-33 {ECO:0000313|EMBL:BAF75157.1}, and JPN-36
RC {ECO:0000313|EMBL:BAF75175.1};
RA Nishimoto Y., Zheng H., Hasegawa M., Zhong S., Chen Q., Sugimoto C.,
RA Kitamura C., Yogo Y.;
RT "Phylogenetic analysis of subtype IV BK virus.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000123059, ECO:0000313|Proteomes:UP000131077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEA-28 {ECO:0000313|EMBL:BAG75218.1}, NEB-27
RC {ECO:0000313|EMBL:BAG75236.1}, and NGY-19
RC {ECO:0000313|EMBL:BAG75260.1};
RX PubMed=18632955; DOI=10.1099/vir.0.2008/000836-0;
RA Yogo Y., Zhong S., Xu Y., Zhu M., Chao Y., Sugimoto C., Ikegaya H.,
RA Shibuya A., Kitamura T.;
RT "Conserved archetypal configuration of the transcriptional control region
RT during the course of BK polyomavirus evolution.";
RL J. Gen. Virol. 89:1849-1856(2008).
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AB217919; BAE53655.1; -; Genomic_DNA.
DR EMBL; AB211391; BAE96084.1; -; Genomic_DNA.
DR EMBL; AB211390; BAF03036.1; -; Genomic_DNA.
DR EMBL; AB269837; BAF75157.1; -; Genomic_DNA.
DR EMBL; AB269840; BAF75175.1; -; Genomic_DNA.
DR EMBL; AB365140; BAG75218.1; -; Genomic_DNA.
DR EMBL; AB365143; BAG75236.1; -; Genomic_DNA.
DR EMBL; AB365147; BAG75260.1; -; Genomic_DNA.
DR Proteomes; UP000098006; Genome.
DR Proteomes; UP000114475; Genome.
DR Proteomes; UP000123059; Genome.
DR Proteomes; UP000127094; Genome.
DR Proteomes; UP000131077; Genome.
DR Proteomes; UP000133455; Genome.
DR Proteomes; UP000150248; Genome.
DR Proteomes; UP000160026; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039576; P:disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039645; P:perturbation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 3.40.1310.20; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR016392; Lg_T_Ag_polyomavir.
DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003133; T_Ag_DNA-bd.
DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR Pfam; PF06431; Polyoma_lg_T_C; 1.
DR Pfam; PF02217; T_Ag_DNA_bind; 1.
DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS51287; T_AG_OBD; 1.
DR PROSITE; PS51341; ZF_LTAG_D1; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW G1/S host cell cycle checkpoint dysregulation by virus
KW {ECO:0000256|ARBA:ARBA00023309};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00671}.
FT DOMAIN 12..75
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 141..256
FT /note="T-ag OBD"
FT /evidence="ECO:0000259|PROSITE:PS51287"
FT DOMAIN 267..359
FT /note="T-ag D1-type"
FT /evidence="ECO:0000259|PROSITE:PS51341"
FT DOMAIN 402..562
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
FT DNA_BIND 141..256
FT /note="T-ag OBD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT REGION 117..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 80583 MW; 4FFD1CEDF2819BFE CRC64;
MDKVLNREES MELMDLLGLE RAAWGNLPLM RKAYLRKCKE FHPDKGGDED KMKRMNTLYK
KMEQDVKVAH QPDFGTWSSS EVPTYGTEEW ESWWSSFNEK WDEDLFCHED MFASDEEATA
DSQHSTPPKK KRKVEDPKDF PSDLHQFLSQ AVFSNRTLAC FAVYTTKEKA LILYKKLMEK
YSVTFISRHM CAGHNIIFFL TPHRHRVSAI NNFCQKLCTF SFLICKGVNK EYLLYSALTR
DPYYIIEESI QGGLKEHDFN PEEPEETKQV SWKLITEYAV ETKCEDVFLL LGMYLEFQYN
VEECKKCQKK DQPYHFKYHE KHFANATIFA ESKNQKSICQ QAVDTVLAKK RVDTLHMTRE
EMLTDRFNHI LDKMDLIFGA HGNAVLEQYM AGVAWLHCLL PKMDSVIFDF LHCIVFNVPK
RRYWLFKGPI DSGKTTLAAG LLDLCGGKAL NVNLPMERLT FELGVAIDQY MVVFEDVKGT
GAESKDLPSG HGINNLDSLR DYLDGSVKVN LEKKHLNKRT QIFPPGLVTM NEYPVPKTLQ
ARFVRQIDFR PKIYLRKSLQ NSEFLLEKRI LQSGMTLLLL LIWFRPVADF AQDIQSRIVE
WKERLDSEIS MYTFSRMKYN ICMGKCILDI TREEDSETED SGHGSSTESQ SQCSSQVSDT
SAPAEDSQRL DPHSEELHLC KGFQCFKRPK TPPPK
//
