ID VIRBB_BRUA2 Reviewed; 362 AA.
AC Q2YJ82; Q57A24; Q9KIS5;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 01-MAY-2013, entry version 50.
DE RecName: Full=Type IV secretion system protein VirB11;
GN Name=virB11; OrderedLocusNames=BAB2_0058;
OS Brucella abortus (strain 2308).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Brucellaceae; Brucella.
OX NCBI_TaxID=359391;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX PubMed=10940027; DOI=10.1128/JB.182.17.4849-4855.2000;
RA Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT "A homologue of an operon required for DNA transfer in Agrobacterium
RT is required in Brucella abortus for virulence and intracellular
RT multiplication.";
RL J. Bacteriol. 182:4849-4855(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2308;
RX PubMed=16299333; DOI=10.1128/IAI.73.12.8353-8361.2005;
RA Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL Infect. Immun. 73:8353-8361(2005).
CC -!- FUNCTION: The virB operon is essential for intracellular survival
CC and is not involved in the invasion process. Constitutes a major
CC determinant of virulence in mice. Virb11 is essential for
CC pathogenesis in mice but is not required for intracellular
CC survival.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC stationary phase of vegetative growth.
CC -!- SIMILARITY: Belongs to the GSP E family.
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DR EMBL; AF226278; AAF73904.1; -; Genomic_DNA.
DR EMBL; AM040265; CAJ12224.1; -; Genomic_DNA.
DR RefSeq; YP_418303.1; NC_007624.1.
DR ProteinModelPortal; Q2YJ82; -.
DR SMR; Q2YJ82; 12-356.
DR STRING; 359391.BAB2_0058; -.
DR EnsemblBacteria; CAJ12224; CAJ12224; BAB2_0058.
DR GeneID; 3827895; -.
DR KEGG; bmf:BAB2_0058; -.
DR PATRIC; 17847601; VBIBruMel86222_2334.
DR eggNOG; COG0630; -.
DR HOGENOM; HOG000119934; -.
DR KO; K03196; -.
DR OMA; ICYNGDK; -.
DR ProtClustDB; CLSK861887; -.
DR BioCyc; BMEL359391:GJOQ-2301-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006810; P:transport; IEA:InterPro.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR001482; T2SS_protein-E.
DR InterPro; IPR014155; VirB11.
DR Pfam; PF00437; T2SE; 1.
DR TIGRFAMs; TIGR02788; VirB11; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding;
KW Virulence.
FT CHAIN 1 362 Type IV secretion system protein VirB11.
FT /FTId=PRO_0000291436.
FT NP_BIND 182 189 ATP (Potential).
SQ SEQUENCE 362 AA; 40885 MW; 4C32B060F4FC79BD CRC64;
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF CERASAWEYY
AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE RIQIVRPPAC EHGTISVTIR
KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP FEQELLALKE AGDYMSFLRR AVQLERVIVV
AGETGSGKTT LMKALMQEIP FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT
AATLLRSCLR MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK RALSLQHSEK
TQ
//
