ID Q2YJV1_BRUA2 Unreviewed; 351 AA.
AC Q2YJV1;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Bacterial regulatory protein LacI, HTH motif:Periplasmic binding protein/LacI transcriptional regulator {ECO:0000313|EMBL:CAJ13106.1};
GN OrderedLocusNames=BAB2_0940 {ECO:0000313|EMBL:CAJ13106.1};
OS Brucella abortus (strain 2308).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=359391 {ECO:0000313|EMBL:CAJ13106.1, ECO:0000313|Proteomes:UP000002719};
RN [1] {ECO:0000313|EMBL:CAJ13106.1, ECO:0000313|Proteomes:UP000002719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2308 {ECO:0000313|EMBL:CAJ13106.1,
RC ECO:0000313|Proteomes:UP000002719};
RX PubMed=16299333; DOI=10.1128/IAI.73.12.8353-8361.2005;
RG Microbial Genomics Group;
RG Lawrence Livermore National Laboratory;
RG and the Genome Analysis Group;
RG Oak Ridge National Laboratory;
RA Chain P., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.,
RA Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL Infect. Immun. 73:8353-8361(2005).
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC {ECO:0000256|ARBA:ARBA00007639}.
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DR EMBL; AM040265; CAJ13106.1; -; Genomic_DNA.
DR RefSeq; WP_002966323.1; NZ_KN046823.1.
DR AlphaFoldDB; Q2YJV1; -.
DR STRING; 359391.BAB2_0940; -.
DR GeneID; 3827734; -.
DR KEGG; bmf:BAB2_0940; -.
DR PATRIC; fig|359391.11.peg.626; -.
DR HOGENOM; CLU_037628_10_0_5; -.
DR PhylomeDB; Q2YJV1; -.
DR Proteomes; UP000002719; Chromosome II.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR025997; SBP_2_dom.
DR PANTHER; PTHR30146:SF45; CATABOLITE REPRESSOR_ACTIVATOR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13407; Peripla_BP_4; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002719};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transport {ECO:0000256|ARBA:ARBA00022970}.
FT DOMAIN 8..65
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 351 AA; 38599 MW; 0931F73D8766FFBB CRC64;
MHISRKKATI YDLSVLSGSS PSTVSAVLNG TWRKRRISQA TAEAILQLAD QHAYTANRQA
QGLRHSRSGL VGLLLPLHDN RFFSAMAQIF EAHVRARSFC PVVVSASRDP EEERETAETL
ISYAIDELFI CGATDPDGLH ELCEKAALPH VNIDLPGSRA PSVTTDNFAG GKMLTAAIIE
YFGEEAPLQP EDLCLFGGRN DESTRQRICG FHQVKQTVLG ADPEGCVFKT GYSPANTLVA
LNDYRARHGR LPRGLFVNSS INLEGLLRFM AEHPGEPLND IVIGCYDYDP FASFLPFPVI
SILQDVEGMI AKAFDLMERR VTEPELHLIM PKLIAPRSAI TGPLDSLKDI K
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