ID TYSY_STAAB Reviewed; 318 AA.
AC Q2YY40;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Thymidylate synthase;
DE Short=TS;
DE Short=TSase;
DE EC=2.1.1.45;
GN Name=thyA; OrderedLocusNames=SAB1282c;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus
RT aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC biosynthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC dihydrofolate + dTMP.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC type ThyA subfamily.
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DR EMBL; AJ938182; CAI80971.1; -; Genomic_DNA.
DR RefSeq; YP_416759.1; NC_007622.1.
DR HSSP; P00469; 2G86.
DR ProteinModelPortal; Q2YY40; -.
DR SMR; Q2YY40; 3-314.
DR STRING; 273036.SAB1282c; -.
DR EnsemblBacteria; CAI80971; CAI80971; SAB1282c.
DR GeneID; 3794329; -.
DR KEGG; sab:SAB1282c; -.
DR PATRIC; 19523437; VBIStaAur92441_1367.
DR eggNOG; COG0207; -.
DR HOGENOM; HOG000257899; -.
DR KO; K00560; -.
DR OMA; DTNVAYL; -.
DR ProtClustDB; PRK01827; -.
DR BioCyc; SAUR273036:GJVS-1304-MONOMER; -.
DR UniPathway; UPA00575; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.572.10; -; 2.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1; -.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylat_synth_C; 1.
DR TIGRFAMs; TIGR03284; thym_sym; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Methyltransferase;
KW Nucleotide biosynthesis; Transferase.
FT CHAIN 1 318 Thymidylate synthase.
FT /FTId=PRO_1000000688.
FT ACT_SITE 201 201 By similarity.
SQ SEQUENCE 318 AA; 36839 MW; E0B26E8B12B77D65 CRC64;
MLNSFDAAYH SLCEEVLEIG NTRNDRTNTG TISKFGHQLR FDLSKGFPLL TTKKVSFKLV
ATELLWFIKG DTNIQYLLKY NNNIWNEWAF ENYIKSDEYK GPDMTDFGHR ALSDPEFNEQ
YKEQMKQFKQ RILEDDTFAK QFGDLGNVYG KQWRDWVDKD GNHFDQLKTV IEQIKHNPDS
RRHIVSAWNP TEIDTMALPP CHTMFQFYVQ DGKLSCQLYQ RSADIFLGVP FNIASYALLT
HLIAKECGLE VGEFVHTFGD AHIYSNHIDA IQTQLARESF NPPTLKINSD KSIFDINYED
LEIVDYESHP AIKAPIAV
//
