ID Q30T65_SULDN Unreviewed; 669 AA.
AC Q30T65;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Suden_0537 {ECO:0000313|EMBL:ABB43816.1};
OS Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira
OS denitrificans (strain ATCC 33889 / DSM 1251)).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Sulfurimonadaceae; Sulfurimonas.
OX NCBI_TaxID=326298 {ECO:0000313|EMBL:ABB43816.1, ECO:0000313|Proteomes:UP000002714};
RN [1] {ECO:0000313|EMBL:ABB43816.1, ECO:0000313|Proteomes:UP000002714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33889 / DSM 1251 {ECO:0000313|Proteomes:UP000002714};
RX PubMed=18065616; DOI=10.1128/AEM.01844-07;
RA Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J.,
RA Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A.,
RA Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E.,
RA Fitzpatrick K.A., Glover B., Gwatney N., Korajkic A., Long A.,
RA Mobberley J.M., Pantry S.N., Pazder G., Peterson S., Quintanilla J.D.,
RA Sprinkle R., Stephens J., Thomas P., Vaughn R., Weber M.J., Wooten L.L.;
RT "Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas
RT denitrificans.";
RL Appl. Environ. Microbiol. 74:1145-1156(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000153; ABB43816.1; -; Genomic_DNA.
DR RefSeq; WP_011372170.1; NC_007575.1.
DR AlphaFoldDB; Q30T65; -.
DR STRING; 326298.Suden_0537; -.
DR REBASE; 11531; SdeAORF537P.
DR KEGG; tdn:Suden_0537; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_015410_1_0_7; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000002714; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 2.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABB43816.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002714};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 335..482
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 487..601
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 669 AA; 75335 MW; 5719B3AF1D9BF2A8 CRC64;
MALYKLEDHV NDWVKAKLEA LNLKNQKDYH TESAIPDYLK EALQGRAKTE KKTNFGKPDF
SITKYKQAPI VIENKLGLKK LIEETKDGVK FDEKSISNYA VNGALYYATG MIASGKYHEV
IAIGIAGDGD DAIELKVYYV YGSGENSFKL LENVSTLDFL ENQKTFDVFY KDAILTEDEK
HEILIKSQAE LQKYSKSLNK LMHNHNITAP QRVLYVSGML LSMQNVVDTK GTKIQDGLVP
QDLKGVQTES KRDAIQIVNQ IKEFLTARNI PIEKQNLMLS SFYEISKDVQ RDELEILDKE
VSKLIDGKAS INKQIFTFIY HNIFLSIDAM AGHLDIMGEM YSEFLKYALG DGKEIGIVLT
PPYITKMMTT ILGVNQNSKV MDLATGSAGF LISSMEMMID DAEANYGKET TAAKKKIDII
KKEQLLGVEL NAEMFTLAAT NMILRGDGSS NIHKGNTFNT PEQLYTSFKA NKLLLNPPFS
YDENGMPFIA FGLDKMEKGG LGAIIIQDSA GSGKATKSNQ AMLKKHTLKA SIKMPTDLFQ
PMAGVQTSIY VLEAHKPHDF EQTVKFIDFR NDGYKRTSRA LQEIDEPTKR YADIVKIYKA
GKNAKVEAPW NLNEVYIEDF ITPSGSDWNF DQHKTIDSKP TLEYFKKTVS DYLSWEVSNI
LKQRGDKGK
//
