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Database: UniProt
Entry: Q317S4_DESAG
LinkDB: Q317S4_DESAG
Original site: Q317S4_DESAG 
ID   Q317S4_DESAG            Unreviewed;       436 AA.
AC   Q317S4;
DT   06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   06-DEC-2005, sequence version 1.
DT   25-OCT-2017, entry version 100.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=Dde_0001 {ECO:0000313|EMBL:ABB36802.1};
OS   Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans
OS   (strain G20)).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=207559 {ECO:0000313|EMBL:ABB36802.1, ECO:0000313|Proteomes:UP000002710};
RN   [1] {ECO:0000313|EMBL:ABB36802.1, ECO:0000313|Proteomes:UP000002710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G20 {ECO:0000313|EMBL:ABB36802.1,
RC   ECO:0000313|Proteomes:UP000002710};
RX   PubMed=21685289; DOI=10.1128/JB.05400-11;
RA   Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L.,
RA   Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C.,
RA   Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A.,
RA   Lucas S., Nolan M., Lapidus A.L., Palumbo A.V., Wall J.D.;
RT   "Complete genome sequence and updated annotation of Desulfovibrio
RT   alaskensis G20.";
RL   J. Bacteriol. 193:4268-4269(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP000112; ABB36802.1; -; Genomic_DNA.
DR   RefSeq; WP_011366205.1; NC_007519.1.
DR   ProteinModelPortal; Q317S4; -.
DR   STRING; 207559.Dde_0001; -.
DR   EnsemblBacteria; ABB36802; ABB36802; Dde_0001.
DR   KEGG; dde:Dde_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000227577; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DALA207559:GH1L-1-MONOMER; -.
DR   Proteomes; UP000002710; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002710};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002710}.
FT   DOMAIN      132    259       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      341    410       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   436 AA;  49843 MW;  95DFAEDFE102D158 CRC64;
     MLKKALRQHF RQSCTEQDLH RWFDPLDITL ADEKRLEVRF PHRFFAEWFS TQVQGRFESE
     LNTFMGEGTT VEYTTGCCPV LSSSPLPPAA VSKKLSAPFG REYTFETFIS NKRNFFPVAS
     ARELARQEEE IRYNPFVLCG PAGSGKTHLL RAIANELSKT VYKKHIFIST IDDLGTLFSN
     NGSGDPAQVR QQLSACHYLL LDDLHRLREQ PQLQDELTVL FNSFYDRQKQ MVFTCPGKLS
     ELDFLETGLR SRLEWGLIVT MKPPDLEILV TFIQRQCKLH KLQLAKEHVF TLAQRFRDFR
     HLQGVLNRLT AYRDLVNRTL ADTDFEQVLS HTEAGAGRPL TADRIIALCA GRFSLPPKDV
     TGDKRHQKVV LARQVAMYLC RELMGSSYPV LGRTFGGKDH STAMYAVKKI KKMIDSDKTT
     RQLVTELKKQ CLSGAE
//
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