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Database: UniProt
Entry: Q31NP2_SYNE7
LinkDB: Q31NP2_SYNE7
Original site: Q31NP2_SYNE7 
ID   Q31NP2_SYNE7            Unreviewed;       469 AA.
AC   Q31NP2;
DT   06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   06-DEC-2005, sequence version 1.
DT   25-OCT-2017, entry version 88.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate decarboxylating) {ECO:0000313|EMBL:ABB57327.1};
DE            EC=1.1.1.38 {ECO:0000313|EMBL:ABB57327.1};
GN   OrderedLocusNames=Synpcc7942_1297 {ECO:0000313|EMBL:ABB57327.1};
OS   Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=1140 {ECO:0000313|EMBL:ABB57327.1, ECO:0000313|Proteomes:UP000002717};
RN   [1] {ECO:0000313|Proteomes:UP000002717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 {ECO:0000313|Proteomes:UP000002717};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC
RT   7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
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DR   EMBL; CP000100; ABB57327.1; -; Genomic_DNA.
DR   RefSeq; WP_011242570.1; NC_007604.1.
DR   ProteinModelPortal; Q31NP2; -.
DR   STRING; 1140.Synpcc7942_1297; -.
DR   PRIDE; Q31NP2; -.
DR   EnsemblBacteria; ABB57327; ABB57327; Synpcc7942_1297.
DR   KEGG; syf:Synpcc7942_1297; -.
DR   eggNOG; ENOG4107QU4; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   HOGENOM; HOG000132447; -.
DR   KO; K00027; -.
DR   OrthoDB; POG091H02AU; -.
DR   BioCyc; SYNEL:SYNPCC7942_1297-MONOMER; -.
DR   Proteomes; UP000002717; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002717};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABB57327.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002717}.
FT   DOMAIN       95    228       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      240    457       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    116    116       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    171    171       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       213    213       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       214    214       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       239    239       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   469 AA;  49179 MW;  030E95E14E40A00F CRC64;
     MASALTPNAS HSVSVLVRMP SNTAAMLHVV QAIATTGANL TEMELLQRTN QWIDRRLIVE
     AASEEQAAAV VEAIAAVPDL ELLDSEDRTF ALHRGGKISV EPKLPLTSQA QLAMAYTPGV
     GRVCKAIAAN PDRVYELTVK QNMVAIVTDG TAVLGLGNLG PAGALPVMEG KAMLFKAFGD
     VDAFPICLDT QDTDEIVETM KRIAPVFGGV NLEDIAAPRC FEIEARLKQE LDIPVFHDDQ
     HGTAIVTLAA LENALKLVKK SLSQVRIVMN GAGAAGLSVA SLLREAGATN IIICDSRGIL
     SCDRSDLTPQ KQAFAIEAGG SLADALVNAD VFIGVSVPGV LTVEMVETMA SDRIIFAMAN
     PIPEIQPELI QGRAAVIATG RSDYPNQINN VLAFPGVFRG ALDCRAKSLT SSMFLAAARA
     IAALVPPETL SAEHIVPSAF DSRVAPAVAA AVVEAAQANG LAQTLAVTH
//
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