ID Q31YC8_SHIBS Unreviewed; 421 AA.
AC Q31YC8;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=Ribosomal protein uL3 glutamine methyltransferase {ECO:0000256|HAMAP-Rule:MF_02125};
DE Short=uL3 MTase {ECO:0000256|HAMAP-Rule:MF_02125};
DE EC=2.1.1.298 {ECO:0000256|HAMAP-Rule:MF_02125};
DE AltName: Full=N5-glutamine methyltransferase PrmB {ECO:0000256|HAMAP-Rule:MF_02125};
GN Name=yfcB {ECO:0000313|EMBL:ABB66931.1};
GN Synonyms=prmB {ECO:0000256|HAMAP-Rule:MF_02125};
GN OrderedLocusNames=SBO_2368 {ECO:0000313|EMBL:ABB66931.1};
OS Shigella boydii serotype 4 (strain Sb227).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=300268 {ECO:0000313|EMBL:ABB66931.1, ECO:0000313|Proteomes:UP000007067};
RN [1] {ECO:0000313|EMBL:ABB66931.1, ECO:0000313|Proteomes:UP000007067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sb227 {ECO:0000313|EMBL:ABB66931.1,
RC ECO:0000313|Proteomes:UP000007067};
RX PubMed=16275786; DOI=10.1093/nar/gki954;
RA Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA Jin Q.;
RT "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT bacillary dysentery.";
RL Nucleic Acids Res. 33:6445-6458(2005).
CC -!- FUNCTION: Specifically methylates ribosomal protein uL3 on 'Gln-150'.
CC {ECO:0000256|HAMAP-Rule:MF_02125}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine
CC = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-
CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:45020, Rhea:RHEA-COMP:11063,
CC Rhea:RHEA-COMP:11064, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891;
CC EC=2.1.1.298; Evidence={ECO:0000256|HAMAP-Rule:MF_02125};
CC -!- SIMILARITY: Belongs to the protein N5-glutamine methyltransferase
CC family. PrmB subfamily. {ECO:0000256|HAMAP-Rule:MF_02125}.
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DR EMBL; CP000036; ABB66931.1; -; Genomic_DNA.
DR AlphaFoldDB; Q31YC8; -.
DR KEGG; sbo:SBO_2368; -.
DR HOGENOM; CLU_018398_5_0_6; -.
DR Proteomes; UP000007067; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0036009; F:protein-glutamine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_02125; L3_methyltr_PrmB; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR017127; Ribosome_uL3_MTase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 1.
DR NCBIfam; TIGR03533; L3_gln_methyl; 1.
DR PANTHER; PTHR47806; 50S RIBOSOMAL PROTEIN L3 GLUTAMINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR47806:SF1; 50S RIBOSOMAL PROTEIN L3 GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_02125,
KW ECO:0000313|EMBL:ABB66931.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_02125}; Transferase {ECO:0000256|HAMAP-Rule:MF_02125}.
FT DOMAIN 243..326
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 421 AA; 47818 MW; 811D6FBF01D236A2 CRC64;
MAGISLLLDQ AFHRHFADFF TLRSVDNRVL LNLASPRHQL AKQSLVLLAK CCFLFHLSVS
ISNFPTVYPT RSTIDRFKRI FPHSPRVNAD LSSSSWQTSR RNYCDHALEE YVDKIFVDEA
VNELQTIQDM LRWSVSRFSA ANIWYGHGTD NPWDEAVQLV LPSLYLPLDI PEDMRTARLT
SSEKHRIVER VIRRVNERIP VAYLTNKAWF CGHEFYVDER VLVPRSPIGE LINNKFAGLI
SKQPQHILDM CTGSGCIAIA CAYAFPDAEV DAVDISPDAL AVAEQNIEEH GLIHNVIPIR
SDLFRDLPKV QYDLIVTNPP YVDAEDMSDL PNEYRHEPEL GLASGTDGLK LTRRILGNAA
DYLADDGVLI CEVGNSMVHL MEQYPDVPFT WLEFDNGGDG VFMLTKEQLL AAREYFAIYK
D
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