ID Q32QB0_ONCMY Unreviewed; 489 AA.
AC Q32QB0;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=CD4 {ECO:0000313|EMBL:AAY42070.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:AAY42070.1};
RN [1] {ECO:0000313|EMBL:AAY42070.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16951357;
RA Laing K.J., Zou J.J., Purcell M.K., Phillips R., Secombes C.J.,
RA Hansen J.D.;
RT "Evolution of the CD4 family: teleost fish possess two divergent forms of
RT CD4 in addition to lymphocyte activation gene-3.";
RL J. Immunol. 177:3939-3951(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AY973030; AAY42070.1; -; Genomic_DNA.
DR RefSeq; NP_001118011.1; NM_001124539.1.
DR AlphaFoldDB; Q32QB0; -.
DR GeneID; 100136285; -.
DR KEGG; omy:100136285; -.
DR CTD; 799982; -.
DR OrthoDB; 4126583at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR PANTHER; PTHR11422:SF8; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR Pfam; PF00047; ig; 1.
DR SMART; SM00409; IG; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..489
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004220863"
FT TRANSMEM 434..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..206
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..338
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 353..424
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 489 AA; 54965 MW; 9E297F4BFE042E58 CRC64;
MKCVSGFLSI IIALFISSTG AEDVVVYGQV GETVTLPRSK WGSERVLVQW FFGIDTQPLI
SRNSHGRETI DPEWKDRLSL SKTDFSLIIN NIRLEDFKSF KCELKDFMPQ TSTSVTFRLF
RVSVQPVSPL LAGKNLNLKC DIEEIFKGTQ RRWLSPQKQD LNEDKRAQIR NDGSLTVMSV
TDQDHGEWTC VVTYQGREAY ANTHVTVIDL SPAHPQPIYT SVSSLSLLHL PCFLSIPPPL
SWSDSQEKSI QGGRWTFTPS PAAGSLTGVV QTLANLSLGP PLAWVVNQKR ELDVSALQRT
NLNLSLSKKG VTEGDRGEYT CAVEFQRGDT LKRSMRVEVL QVFSSPAPVA FVGQEVNLTC
TLGHPLTSDL KVKWIPPRQS SLLALGSAPD SAHLTIPEAR DINGGRWRCE LWRNKTKLTS
VEITLKIERV PMDVWLLVTI CDAAVIFVLL LILTVILNRR HRQRVTMPRR GKRRICRCKD
PQPKGFYRN
//
