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Database: UniProt
Entry: Q37605
LinkDB: Q37605
Original site: Q37605 
ID   COX2_PONPY              Reviewed;         227 AA.
AC   Q37605; P92721; P92722; Q37606; Q37607;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   01-OCT-2014, entry version 98.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=MT-CO2; Synonyms=COII, COXII, MTCO2;
OS   Pongo pygmaeus (Bornean orangutan).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-4; SER-54; ILE-67;
RP   LEU-184 AND THR-226.
RC   STRAIN=Isolate San Diego zoo Ppy2, and Isolate San Diego zoo Ppy3;
RX   PubMed=8090741; DOI=10.1073/pnas.91.19.8900;
RA   Ruvolo M., Pan D., Zehr S., Goldberg T., Disotell T.R., von Dornum M.;
RT   "Gene trees and hominoid phylogeny.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:8900-8904(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA   Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT   "Recent African origin of modern humans revealed by complete sequences
RT   of hominoid mitochondrial DNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-4; ILE-38 AND
RP   ILE-67.
RC   STRAIN=Isolate Anna, and Isolate Dennis;
RX   PubMed=8875856; DOI=10.1007/BF02337514;
RA   Xu X., Arnason U.;
RT   "The mitochondrial DNA molecule of Sumatran orangutan and a molecular
RT   proposal for two (Bornean and Sumatran) species of orangutan.";
RL   J. Mol. Evol. 43:431-437(1996).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000305}.
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DR   EMBL; U12703; AAA61412.1; -; Genomic_DNA.
DR   EMBL; U12704; AAA61413.1; -; Genomic_DNA.
DR   EMBL; D38115; BAA07308.1; -; Genomic_DNA.
DR   EMBL; X97716; CAA66302.1; -; Genomic_DNA.
DR   EMBL; X97712; CAA66298.1; -; Genomic_DNA.
DR   PIR; I61892; I61892.
DR   PIR; T14142; T14142.
DR   RefSeq; NP_008228.1; NC_001646.1.
DR   ProteinModelPortal; Q37605; -.
DR   SMR; Q37605; 1-220.
DR   GeneID; 807910; -.
DR   CTD; 4513; -.
DR   eggNOG; COG1622; -.
DR   HOGENOM; HOG000264988; -.
DR   HOVERGEN; HBG012727; -.
DR   InParanoid; Q37605; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:1902600; P:hydrogen ion transmembrane transport; ISS:GOC.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Polymorphism; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    227       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000183670.
FT   TOPO_DOM      1     26       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   TRANSMEM     27     48       Helical. {ECO:0000255}.
FT   TOPO_DOM     49     62       Mitochondrial matrix. {ECO:0000255}.
FT   TRANSMEM     63     82       Helical. {ECO:0000255}.
FT   TOPO_DOM     83    227       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   METAL       161    161       Copper A. {ECO:0000250}.
FT   METAL       196    196       Copper A. {ECO:0000250}.
FT   METAL       200    200       Copper A. {ECO:0000250}.
FT   METAL       204    204       Copper A. {ECO:0000250}.
FT   VARIANT       4      4       R -> A (in strain: Isolate San Diego zoo
FT                                Ppy3, Isolate Anna and Isolate Dennis).
FT                                {ECO:0000269|PubMed:8090741,
FT                                ECO:0000269|PubMed:8875856}.
FT                                /FTId=VAR_019058.
FT   VARIANT      38     38       V -> I (in strain: Isolate Anna).
FT                                {ECO:0000269|PubMed:8875856}.
FT                                /FTId=VAR_019554.
FT   VARIANT      54     54       N -> S (in strain: Isolate San Diego zoo
FT                                Ppy3, Isolate Anna and Isolate Dennis).
FT                                {ECO:0000269|PubMed:8090741}.
FT                                /FTId=VAR_019059.
FT   VARIANT      67     67       T -> I (in strain: Isolate San Diego zoo
FT                                Ppy3). {ECO:0000269|PubMed:8090741,
FT                                ECO:0000269|PubMed:8875856}.
FT                                /FTId=VAR_019060.
FT   VARIANT     184    184       F -> L (in strain: Isolate San Diego zoo
FT                                Ppy3). {ECO:0000269|PubMed:8090741}.
FT                                /FTId=VAR_019061.
FT   VARIANT     226    226       A -> T (in strain: Isolate San Diego zoo
FT                                PPY3). {ECO:0000269|PubMed:8090741}.
FT                                /FTId=VAR_019062.
SQ   SEQUENCE   227 AA;  25652 MW;  D027088B63F57A42 CRC64;
     MAHRAQVGLQ DATSPIMEEL VIFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METIWTTLPA IILILIALPS LRILYLTDEI NDPSFTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV RMMITSQDVL HSWTVPSLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFAL
//
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