ID Q383C5_TRYB2 Unreviewed; 604 AA.
AC Q383C5;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=Tb11.01.3380 {ECO:0000313|EMBL:EAN80106.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN80106.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN80106.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN80106.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; CH464491; EAN80106.1; -; Genomic_DNA.
DR RefSeq; XP_829218.1; XM_824125.1.
DR AlphaFoldDB; Q383C5; -.
DR STRING; 185431.Q383C5; -.
DR PaxDb; 5691-EAN80106; -.
DR GeneID; 3665059; -.
DR KEGG; tbr:Tb11.01.3380; -.
DR VEuPathDB; TriTrypDB:Tb927.11.11530; -.
DR eggNOG; KOG2747; Eukaryota.
DR InParanoid; Q383C5; -.
DR OrthoDB; 127450at2759; -.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR GO; GO:0004402; F:histone acetyltransferase activity; ISA:GeneDB.
DR GO; GO:0010485; F:histone H4 acetyltransferase activity; IDA:GeneDB.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0016573; P:histone acetylation; IDA:GeneDB.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.40.630.30; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF214; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF01853; MOZ_SAS; 2.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 165..587
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 417
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 604 AA; 67667 MW; 3C38D62EE7B0E95D CRC64;
MASLAAKKDG GDINGGPSEE EDQLQQLLGT SCCVNLSDST VKRGFLLEVR YLWLPRLLSG
NGTTGVAPQL YGFVRIKDAD HRISGWFPID CIDLKETGGA NGATSCGSSY PTNSAAYNSM
VVAKSKITHP IISPVYREVT PGMVRTRREG KQLDFFEERL LRDCRTPTTV RYFIYLCKFA
FPPWYYAPYG MLNREYDPLA PLSDAEREAL RFTEGSTNES IDTNPFIRDA YLCPFSLRIY
STFEQMQHET LRYRAGHLHP PGLEIYRDDT RGFSMFEVNG SRHVTYCRHL FLLGKSFLEN
KLAGHDVHNY YFYVVCLHHR HYPHYTDDTS AMYFVGYFTW EKQVTDNNLA CIVTLPYFMG
GGASSGQQND LSDDRGPVGA DTASREGDTP KLGHFGQFMI AASYELAYRR KNVGSPEKPL
TDLGAAAYDR YWKRVLIKWM HTLLEGNAAA ITVDDDAGDD GQSVTIVVAH ENEAKMAAPG
ALKRPRPGTT DGSGCAEAVR GARVAEGDTL VDTTVRSIAK QVRLEEADVL RTLLQMGVLH
LNAEDRSMRV VIPVSFVNRE YGKMKKWAHD MTRAEFDPKL LTGRGGPAWL VNTPSPRRHN
QHQS
//
