ID Q384G5_TRYB2 Unreviewed; 571 AA.
AC Q384G5;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN ORFNames=Tb11.01.0050 {ECO:0000313|EMBL:EAN79816.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN79816.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN79816.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79816.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
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DR EMBL; CH464491; EAN79816.1; -; Genomic_DNA.
DR RefSeq; XP_828928.1; XM_823835.1.
DR AlphaFoldDB; Q384G5; -.
DR STRING; 185431.Q384G5; -.
DR PaxDb; 5691-EAN79816; -.
DR GeneID; 3665084; -.
DR KEGG; tbr:Tb11.01.0050; -.
DR eggNOG; KOG2094; Eukaryota.
DR InParanoid; Q384G5; -.
DR OrthoDB; 146204at2759; -.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EAN79816.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transferase {ECO:0000313|EMBL:EAN79816.1}.
FT DOMAIN 135..318
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT COILED 75..132
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 571 AA; 63406 MW; 9E8738DEC5A329D6 CRC64;
MCGGEENGGL DQAHVSYSGS ASEQNIAEMI VDPSGSRQPT AFQLTLDCNK AGMGNVDKER
VEAIIRNVSE GSSFLMNEQR KAEGREKQLQ ELKRKSSLFT RLLGGERNAA QRKQWELKVS
KIEQELEATR RLGTYIHLDM DMFYAAVEIK KHPEYAAIPL AIGTITRLIT TNYVARGRGI
RQGMPGFLAL KICPNLLILP PDFDAYNEES NTVRRIVAEY DPNYISFGLD DFTLEVSAYI
ERFEGTKTAE DVASELRVRV FGETKLTASA GIGPTAALAK IASNINKPNG QHDLNLHTRE
DVMTYVRDLG LRSVPGVGKV TEALLKGLGI TTLSDIYNRR VELCYILHNN LFRFLLGASI
GIMQWPDAAT AANTENCEGA TGEQRKAISS ERSITTPRTK EGMQEMLDTV FNGAYEEMRK
SEIMCRRISL TIRWASYRYQ QYTKSLIQHS DDSATLRRAV DGLLLPHAAK YSEMCLLGVR
LSDLISAKDF HMKRKGGNQL SISQFIRPKK PGEVTATTGI KRERTTEPKQ VVEIIISSDD
EDENDSVGLA SSSTILVSTG KGTVEREVTI I
//
