ID Q387D6_TRYB2 Unreviewed; 1107 AA.
AC Q387D6;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Pep3/Vps18/deep orange beta-propeller domain-containing protein {ECO:0000259|Pfam:PF05131};
GN ORFNames=Tb11.47.0033 {ECO:0000313|EMBL:EAN79095.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN79095.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN79095.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN79095.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; CH464491; EAN79095.1; -; Genomic_DNA.
DR RefSeq; XP_828207.1; XM_823114.1.
DR AlphaFoldDB; Q387D6; -.
DR STRING; 185431.Q387D6; -.
DR PaxDb; 5691-EAN79095; -.
DR GeneID; 3665693; -.
DR KEGG; tbr:Tb11.47.0033; -.
DR eggNOG; KOG2034; Eukaryota.
DR InParanoid; Q387D6; -.
DR OrthoDB; 160969at2759; -.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR InterPro; IPR007810; Pep3_Vps18.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 37..525
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT COILED 974..1001
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1107 AA; 122930 MW; CABC9CE988FA098F CRC64;
MKALSDDSLP SFRLGSQGNL AAVPTKGPSP RFELAPIVNE LQQQIISADC QSDVIAMLGA
SGRLVLRDTM QDGPPLVTSV RNPYRVFMSP DGNHTLVSTT DGELCYFSVR NRKSTGHFTL
HNRGASGNEA ARNNVASCVC WLSSDAGFIG SPRTSISGAE GVSGSGSGWQ LGSGTVYCLV
GTKLGGLVFL VKVEVHGDGG SVKLTCFRSL QLPDANPQQQ VGSVEVEHIN SLWVLFVSTP
TVLYRVEGLM DSPADFFDSI TASTGMWNIR RVSTAGNASA SGAVVLYRPG IGMPAQSYAW
ASVAGVVHGL LNSRSDGSSA NSGEAALVEL TDGGSVVNEQ LLDLEHVVVP KSSSNESAAI
TAAVPDHSFR GESQLPVGAT LVDVGLTAFH MLLLYRDRFI VLNHPAGLSW RGASSTLQGD
WPYLCEIEER IRFDPFRYSK RESPLRGIVR DTAARKVYVF DANTFWELQV EQEHRQQSEL
FLDRAVNTRE SSHLRNRYFR AAYQLCKYDK TMRNKVQFLR GRFLLQIGAI RRAMDVLAEC
DFFEDVYHLL MSFRNSKVLQ LYVEKRYKNL VRRVTEGKGV QMQLACLLAL IVVLRLDTIA
RSENITDAPS ATAVAETLTS GLTAFIEETL EERLPMFSCV GYVNLIAQLL EEQSRPELVL
RFAERMNKMR YVITYHVSRA NYVEAANVLG AHARRIDMRS TWYSLAPILM KKCPIQFTKA
MLRAVSRDAY DMPYLLLNAE KLIPVFTQYE PHMNEDPDNQ EHQVVLFLDN CITKLGCDSP
AVHNYYLSLV VKHDTKRLDE FLQSSLYYDI RFALRQCLES RRYRQCVRLY SQLHLYEDAL
RAALDCAELT QDETPGGASS AIVGSGVNEC AATSLVSGAD LGCNEGEERD AWSRLSVAQE
LLLSLPDDMP LPRRKALWLI VAQHVIQKND NRAALRILAD SCGVLKLEDI LEEMNDVSVM
ENFKGAICKS LEVYASLTKQ LREKQLEAGR MSEELKREIE QPRNSFGYVT ANQRCIICRS
TLLQGDAPFF IYPRCCHAVH ESCAVAKLES IGGLEAFVVD EGLPKNFLDG INSTRDLAQM
DCVICGETAI LEIDMPLFTE DDSWLVL
//
