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Database: UniProt
Entry: Q38BV7_TRYB2
LinkDB: Q38BV7_TRYB2
Original site: Q38BV7_TRYB2 
ID   Q38BV7_TRYB2            Unreviewed;      2693 AA.
AC   Q38BV7;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   05-JUL-2017, entry version 85.
DE   SubName: Full=Calcium channel protein, putative {ECO:0000313|EMBL:EAN77713.1};
GN   ORFNames=Tb10.70.4750 {ECO:0000313|EMBL:EAN77713.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN77713.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77713.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B.,
RA   Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L.,
RA   Wickstead B., Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J.,
RA   Bringaud F., Brooks K., Carrington M., Cherevach I.,
RA   Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A.,
RA   Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C.,
RA   Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H.,
RA   Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K.,
RA   Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V.,
RA   Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M.,
RA   Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S.,
RA   Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A.,
RA   Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B.,
RA   White O., Whitehead S., Woodward J., Wortman J., Adams M.D.,
RA   Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H.,
RA   Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M.,
RA   Melville S.E., El-Sayed N.M.A.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
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DR   EMBL; CM000208; EAN77713.1; -; Genomic_DNA.
DR   RefSeq; XP_822541.1; XM_817448.1.
DR   ProteinModelPortal; Q38BV7; -.
DR   STRING; 5691.EAN77713; -.
DR   TCDB; 1.A.1.11.24; the voltage-gated ion channel (vic) superfamily.
DR   EnsemblProtists; EPrT00001299378; EPrP00001314414; EPrG00001287584.
DR   GeneDB; Tb927.10.2880:pep; -.
DR   GeneID; 3662219; -.
DR   KEGG; tbr:Tb10.70.4750; -.
DR   EuPathDB; TriTrypDB:Tb927.10.2880; -.
DR   HOGENOM; HOG000260229; -.
DR   InParanoid; Q38BV7; -.
DR   OMA; FWRLICD; -.
DR   Proteomes; UP000008524; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR020846; MFS_dom.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008524};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    403    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    466    486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1045   1065       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1077   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1119   1139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1159   1189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1209   1226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1246   1271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1774   1794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1806   1828       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1840   1861       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1897   1922       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2005   2031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2085   2107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2113   2133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2145   2164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2215   2237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2299   2323       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      333    606       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1048   1256       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1773   2031       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2084   2328       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2340   2399       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2693 AA;  303776 MW;  673A56636E6B95B0 CRC64;
     MAEPPPPQPL RKGFFRADPH GLRPPESPRD AEEPENHDIV EDPPLPSSRN LPPPRLRPMG
     GGPPLAGAEA AATSHSNNRP SPGEVPPLPR PGTTTAVTSA QYNSLTPRQE LFSSPQTAVE
     ENIPAGYDNQ MNVTSNDFSH SQDTGIKRIG DGATGSSAKT RSTIAHAPSG RFSEVVQERP
     PIESVEQLCQ LQTLAHPVER FFVEYQPMAT RGCRSTQVPV EEDEALFNHL AEYTDDDSFF
     SSGSAVLEED TRRLQNDPLR GRAIRSVFET LSLRSLTKGR IPYELEDQER SSAPWLKQVH
     QRAIALHHSS FFIFPAGMKA RVIAYNILHH WLTEMLLMLI ILVYSMMTAA WSRDTWPTLE
     KPSFMFFADV FFLCIYAIEF VARLFTSGAV SHSRAYFRSP WHCLDAAVLL LMILNCTNLQ
     SMWNFSAFRL IRVLKSSTYV PIPINMKLLA KSLLRSTSNV VKVSTILFYV LLFFSLVGLQ
     LFSGVLQHRC VSPTTKNVTN QLCRFNHSEK NESYYHGATC PSPHLCVADT YGNPHHGYRS
     FDSVGHSFLS AFQIMTFQGW TSLLQETSDT TSVAAILYFF LAILICAWII PSLYLGVFIE
     KIEKTRRLFV QKQLQLFDGM LLEQRQRLNE AIKLRDFVER DESGKLRRHP IELIRSASRR
     IQRSKLSNSQ TSIATESESG EPAVVVKKPI GDTTKGRSRW TDEQRVQLHL SLTRQRDIAS
     GGERRRRVVI KNDGEISGGT AGLHSQRKGS ESIGERAMMV TGDFALGGRV GVVQHHPLTH
     TIGAAHGTDL PLAVRLDNEE EQLRFLKDYQ NPIDNDIMRR TNTFEDTNGN LHPSFVLTST
     QRRGGSFDEA SNTIRTTTEA AGVIPSRHSA TLNGHNTSRM DSNGSLDEPT SKTQTVSKRG
     SPMPRLSSGQ VPEVIIHDPE GGDFRFAETR SQKWGIVRNI LHMFTEGYPR IITQYIREHR
     RMQRRFGLTP LNYVNKYEDD VLRKLRQRRV LQVKEPGAPS QTSRASGDEE LVEVNGNKVI
     LTDSDDIGDL SPIQMATNIV RNVPVTPFGA VMLVIVIVNG IFNATRYFQQ PEYWETALFV
     LGIIFTSFFV LEIVVRVIGL GLVSFLLDFN NLLDVTVTIL GFVELAYARS NVVTVLNWVR
     LLRLFRTLPF APMRRVSRVL LLGFADMLYA LFFFSIYMFM WILIGMSFFG GPNGMVDHTF
     QDYYTRGNFD TFSGASFAVS QAFSYTREEW VYLTWNGMQS RGEYTVLYFM AVVGVAFIAR
     YFFVAVFAWA WQSEEEEEEN YAAIAKGGSG GRREVTRLRW FDFTVWRSFK HIHGGFERRD
     VAPDEVFHLN EDMRKQLRIA EAKERFTKEA LAQTDLAMSQ RRMGSPMASP SATMGYNTDG
     YAPAAQVGTA PRYVNVGGQL QRHINPSVDF VDAQVPPLNA PISQFQAENA QLRFARRYST
     VPASVYTPVI QDDGIDRPSP SARSSPSDAG ERSGELGGES QQNGQEEGDG QYSPRGVSPN
     GTGGRATSTG LQRKSSVLGR FPRLGYDRAA GKKDGGSRSV SASAMQQTGD GNELRGDYVN
     EGEVNGGSMV YEHILYPGPR LRYKHVMRNQ YVRVFERCLD CNTYQQMPLR APPNVQQRTP
     EELHAEHCHM AAVRSSRQLV LNAIMGYVRL QKDINQPPTR DAVETVLGQA WSCGMLLFET
     IEYLSCSDIE QREYRTWDRT LEALQLQQWL IGLHVGEEQV GRATLAYTLA HRKREKLAVE
     HKSFELSWRQ RSFFFISPSN PVRRLSTRII QSRWFDIFIL TVIFIASFCL CFHIPGKAND
     PETGFVVLRA FDGIFTCIFL VEMIMKWISM GVILFRPEAY FWHWWNVFDF VIVIVSLIGL
     ADQHSALRSI KVLRCFRILI PMRVSNFNRS LSKISSALLD CLPTVANILL LFFINYFVWA
     VLAVRLLNGL THSCSDPSFV DITACEDAKH EWLPKVRNFD SFFQSLLTMI EVSVGSKWLD
     VIYTGVNGRT SEHAPMDDHY LARGFFFIVY YYVSHLILFS LFTASMIYSY LLTKNAAEGV
     LGITFEHQLW IRMQRMTLQL KPRVKLVPLC NHVSQFLHNV VIRPIFEVVG ASVLLLNILT
     MALHWYGETK SKASVLAAFQ YVWMFYFTVE AAMKIGAHGM RAFSRWAFSF DFFVLLLSFI
     GLIVDAASSE GMPFNVNVLR MLRLGRFFSA AKVFKPMRKQ FSLLHEVLIR SAVSLANVTL
     ILFLGVFVFT VLGLHLVGGV PVGEGGYFDD RYTNFNNFGN SLMMTFRLTT LENWSPSLRE
     GMNVTRKCTE DDCSVNYGSA FYCLLLLVFL GLIVLSFYMA VIVDHYVTAA RMNTSITRIE
     DLRRFRDLWS EFDPNGALVL HTHELPKLLE SLRPPLGLTS RHNRVELLRL LREYDIPNHR
     GKVHYHEVLL PLARRVLAMA FSRDTMDYRT TFDTLWRHSE KSLRALPTVL GKRSHATAAQ
     HFAASYVQAV CRRKKACREV QRVRSELWHE GRAVCDELGL PYADYGFGNL LLEGPDPMRD
     LVPRSASAAS SGGKGTRKGA SEAENAASSP LWRAGQAESP SSPRSEGETI DGRAPAARLP
     GAYQPAIEER EKRFGPDVPN ALRRHETRSE KLRRKDEERM LQSTPDDAVS SPVSNVRSNS
     QRVNVGEYQP PLGTDPTSWL GSNVNRGSTV GGPTTESRTS SVMPAPQGPT APE
//
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