UniProt: Q38D64

Database: UniProt
Entry: Q38D64_TRYB2

LinkDB:  Q38D64_TRYB2 
Original site:  Q38D64_TRYB2

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Ontology (8)   
   GO (8)   
Gene (6)   
   KEGG GENES (3)   
   NCBI-Gene (3)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (10)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (2)   
   SMART (3)   
Literature (2)   
   PubMed (2)   
All databases (30)   

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ID   Q38D64_TRYB2            Unreviewed;       182 AA.
AC   Q38D64;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=ADP-ribosylation factor {ECO:0000256|RuleBase:RU369003};
GN   ORFNames=Tb09.211.4470 {ECO:0000313|EMBL:EAN77256.1}, Tb09.211.4480
GN   {ECO:0000313|EMBL:EAN77257.1}, Tb09.211.4490
GN   {ECO:0000313|EMBL:EAN77258.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN77256.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77256.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:EAN77256.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77256.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
CC   -!- FUNCTION: GTP-binding protein involved in protein trafficking;
CC       modulates vesicle budding and uncoating within the Golgi apparatus.
CC       {ECO:0000256|RuleBase:RU369003}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|RuleBase:RU369003}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|ARBA:ARBA00010290, ECO:0000256|RuleBase:RU003925}.
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DR   EMBL; CM000207; EAN77256.1; -; Genomic_DNA.
DR   EMBL; CM000207; EAN77257.1; -; Genomic_DNA.
DR   EMBL; CM000207; EAN77258.1; -; Genomic_DNA.
DR   RefSeq; XP_827586.1; XM_822493.1.
DR   RefSeq; XP_827587.1; XM_822494.1.
DR   RefSeq; XP_827588.1; XM_822495.1.
DR   AlphaFoldDB; Q38D64; -.
DR   STRING; 185431.Q38D64; -.
DR   PaxDb; 5691-EAN77256; -.
DR   GeneID; 3661095; -.
DR   GeneID; 3661096; -.
DR   GeneID; 3661097; -.
DR   KEGG; tbr:Tb09.211.4470; -.
DR   KEGG; tbr:Tb09.211.4480; -.
DR   KEGG; tbr:Tb09.211.4490; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.13655; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.13680; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.13710; -.
DR   VEuPathDB; TriTrypDB:Tb927.9.13740; -.
DR   eggNOG; KOG0070; Eukaryota.
DR   InParanoid; Q38D64; -.
DR   OMA; YYQNTSA; -.
DR   OrthoDB; 5349301at2759; -.
DR   Proteomes; UP000008524; Chromosome 9.
DR   GO; GO:0097014; C:ciliary plasm; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031981; C:nuclear lumen; IDA:GeneDB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd04150; Arf1_5_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045872; Arf1-5-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR   PANTHER; PTHR11711:SF30; ADP-RIBOSYLATION FACTOR 1; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   3: Inferred from homology;
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU369003};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|RuleBase:RU369003};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003925};
KW   Lipoprotein {ECO:0000256|RuleBase:RU369003};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU369003};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003925};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU369003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369003}.
SQ   SEQUENCE   182 AA;  20624 MW;  D2B7CCBBCA820316 CRC64;
     MGQWLASAFK SLVGKQEVRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
     LKFTMWDVGG QDVLRPLWRH YYQNTNGIIF VVDSNDKERV GKARQELEKM LSEDELRNAV
     LLVFANKQDL PNAMSTTEVT EKLGLQSVRQ RNWYIQGCCA TTAQGLYEGL DWLSANIKKS
     MK
//

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