ID Q38JL1_DANRE Unreviewed; 489 AA.
AC Q38JL1; A0A8M1N7V3; F1R7H0;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=Regulator of G-protein signaling 6 {ECO:0000313|Ensembl:ENSDARP00000119214, ECO:0000313|RefSeq:NP_001030340.1};
DE SubName: Full=Rgs6 {ECO:0000313|EMBL:ABB01374.1};
GN Name=rgs6 {ECO:0000313|Ensembl:ENSDARP00000119214,
GN ECO:0000313|RefSeq:NP_001030340.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-31};
GN Synonyms=hm:zeh0300 {ECO:0000313|RefSeq:NP_001030340.1},
GN si:ch211-268e23.2 {ECO:0000313|RefSeq:NP_001030340.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABB01374.1};
RN [1] {ECO:0000313|RefSeq:NP_001030340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11116087;
RA Ton C., Hwang D.M., Dempsey A.A., Tang H.C., Yoon J., Lim M., Mably J.D.,
RA Fishman M.C., Liew C.C.;
RT "Identification, characterization, and mapping of expressed sequence tags
RT from an embryonic zebrafish heart cDNA library.";
RL Genome Res. 10:1915-1927(2000).
RN [2] {ECO:0000313|EMBL:ABB01374.1}
RP NUCLEOTIDE SEQUENCE.
RA Xie W., Chatterjee T.K., Westfall T., Slusarski D., Fisher R.A.;
RT "Isolation and cloning of zebrafish RGS6.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000119214, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119214};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001030340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24947308;
RA Azuaje F.J.;
RT "Selecting biologically informative genes in co-expression networks with a
RT centrality score.";
RL Biol. Direct 9:12-12(2014).
RN [5] {ECO:0000313|RefSeq:NP_001030340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001030340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001030340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000145833}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119214};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [9] {ECO:0000313|RefSeq:NP_001030340.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX255881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX569801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ222439; ABB01374.1; -; mRNA.
DR RefSeq; NP_001030340.1; NM_001035263.1.
DR STRING; 7955.ENSDARP00000119214; -.
DR PaxDb; 7955-ENSDARP00000119214; -.
DR Ensembl; ENSDART00000135513.4; ENSDARP00000119214.2; ENSDARG00000015627.13.
DR Ensembl; ENSDART00000184779.1; ENSDARP00000145833.1; ENSDARG00000015627.13.
DR GeneID; 562667; -.
DR KEGG; dre:562667; -.
DR AGR; ZFIN:ZDB-GENE-030131-31; -.
DR CTD; 9628; -.
DR ZFIN; ZDB-GENE-030131-31; rgs6.
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_025092_4_0_1; -.
DR OMA; PAWRINR; -.
DR OrthoDB; 22856at2759; -.
DR TreeFam; TF351956; -.
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Reactome; R-DRE-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000015627; Expressed in retina and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08737; RGS_RGS6; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR037956; RGS6_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 39..114
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 335..450
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 489 AA; 56570 MW; 7C1D5F60BD842920 CRC64;
MAQASQDQGA VGIADPDEDS PNMIAYRKIE DIITRLQDEA EGVPVRTVKS FLTKIPNVVT
GSDIVQWMMK NLNMEDPAEA IHVGSLIAAQ GYIFPISDHV LTLKDDGTFY RFQAPYFWPS
NCWEPENTDY AIYLCKRTMQ NKTRLELADY EAENLARLQR AFARKWEFIF MQAEAQVKID
RKKDKTERKI LDSQERAFWD VHRPVPGCVN TTEMDIRKCR RLKNPQRVKK SVYGVVDDTQ
TQSPVHTPAQ QSSKDTKEDV EKEILFLNTQ LDRHCMKMSK VAETLMSYTE QYLDYDPFVA
VPEPSNPWIS DDATFWELEA SKDPSQQRVK KWGFSLDEAL KDPVGREQFL KFLESEFSSE
NLLFWLAVQD LKCRPLQEVA SRAQEIWQEF LAEGAPNAIN LDSHSYERTS QNLKDPGRYS
FEDAQDHIYK LMKSDSYPRF LRSNAYQDLL LARKKPETEQ GRRTSLEKFT RSVGKSLTSK
RLTGLMQSS
//
