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Database: UniProt
Entry: Q38S41
LinkDB: Q38S41
Original site: Q38S41 
ID   COX2_MICNA              Reviewed;         227 AA.
AC   Q38S41;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   19-MAR-2014, entry version 45.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=MT-CO2; Synonyms=COII, COXII, MTCO2;
OS   Micaelamys namaquensis (Namaqua rock rat) (Aethomys namaquensis).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Micaelamys.
OX   NCBI_TaxID=472707;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15975830; DOI=10.1016/j.ympev.2005.04.016;
RA   Steppan S.J., Adkins R.M., Spinks P.Q., Hale C.;
RT   "Multigene phylogeny of the Old World mice, Murinae, reveals distinct
RT   geographic lineages and the declining utility of mitochondrial genes
RT   compared to nuclear genes.";
RL   Mol. Phylogenet. Evol. 37:370-388(2005).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR   EMBL; DQ019089; ABA28359.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q38S41; -.
DR   SMR; Q38S41; 1-227.
DR   HOVERGEN; HBG012727; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:1902600; P:hydrogen ion transmembrane transport; ISS:GOC.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Respiratory chain; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    227       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000257850.
FT   TOPO_DOM      1     26       Mitochondrial intermembrane (Potential).
FT   TRANSMEM     27     48       Helical; (Potential).
FT   TOPO_DOM     49     62       Mitochondrial matrix (Potential).
FT   TRANSMEM     63     82       Helical; (Potential).
FT   TOPO_DOM     83    227       Mitochondrial intermembrane (Potential).
FT   METAL       161    161       Copper A (By similarity).
FT   METAL       196    196       Copper A (By similarity).
FT   METAL       200    200       Copper A (By similarity).
FT   METAL       204    204       Copper A (By similarity).
SQ   SEQUENCE   227 AA;  25868 MW;  E4ED2979D709593A CRC64;
     MAYPLQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY IISLMLTTKL THTSTMDAQE
     VETIWTILPA AILVLIALPS LRILYMMDEI NNPVLTVKTM GHQWYWSYEY TDYEDLCFDS
     YMIPTNDLKP GELRLLEVDN RVVLPMELPI RMLISSEDVL HSWAVPSLGL KTDAIPGRLN
     QATVSSNRPG LFYGQCSEIC GSNHSFMPIV LEMVPLKYFE NWSASMI
//
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