ID Q39X46_GEOMG Unreviewed; 104 AA.
AC Q39X46;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=HNH endonuclease family protein {ECO:0000313|EMBL:ABB31178.1};
GN OrderedLocusNames=Gmet_0936 {ECO:0000313|EMBL:ABB31178.1};
OS Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=269799 {ECO:0000313|EMBL:ABB31178.1, ECO:0000313|Proteomes:UP000007073};
RN [1] {ECO:0000313|EMBL:ABB31178.1, ECO:0000313|Proteomes:UP000007073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53774 / DSM 7210 / GS-15
RC {ECO:0000313|Proteomes:UP000007073};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Geobacter metallireducens GS-15.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABB31178.1, ECO:0000313|Proteomes:UP000007073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53774 / DSM 7210 / GS-15
RC {ECO:0000313|Proteomes:UP000007073};
RX PubMed=19473543; DOI=10.1186/1471-2180-9-109;
RA Aklujkar M., Krushkal J., DiBartolo G., Lapidus A., Land M.L., Lovley D.R.;
RT "The genome sequence of Geobacter metallireducens: features of metabolism,
RT physiology and regulation common and dissimilar to Geobacter
RT sulfurreducens.";
RL BMC Microbiol. 9:109-109(2009).
RN [3] {ECO:0007829|PDB:4H9D}
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ZINC.
RA Kuzin A., Chen Y., Seetharaman J., Fang F., Xiao R., Cunningham K., Ma L.,
RA Owens L., Chen C.X., Everett J.K., Acton T.B., Montelione G.T., Hunt J.F.,
RA Tong L.;
RT "Northeast Structural Genomics Consortium Target GmR87.";
RL Submitted (SEP-2012) to the PDB data bank.
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DR EMBL; CP000148; ABB31178.1; -; Genomic_DNA.
DR RefSeq; WP_004514419.1; NC_007517.1.
DR PDB; 4H9D; X-ray; 2.60 A; A/B/C=1-104.
DR PDBsum; 4H9D; -.
DR AlphaFoldDB; Q39X46; -.
DR SMR; Q39X46; -.
DR STRING; 269799.Gmet_0936; -.
DR DNASU; 3740092; -.
DR KEGG; gme:Gmet_0936; -.
DR eggNOG; COG1403; Bacteria.
DR HOGENOM; CLU_158450_0_0_7; -.
DR EvolutionaryTrace; Q39X46; -.
DR Proteomes; UP000007073; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00085; HNHc; 1.
DR Gene3D; 1.10.30.50; -; 1.
DR InterPro; IPR029471; HNH_5.
DR InterPro; IPR003615; HNH_nuc.
DR PANTHER; PTHR33877; SLL1193 PROTEIN; 1.
DR PANTHER; PTHR33877:SF1; TYPE IV METHYL-DIRECTED RESTRICTION ENZYME ECOKMCRA; 1.
DR Pfam; PF14279; HNH_5; 1.
DR SMART; SM00507; HNHc; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4H9D};
KW Endonuclease {ECO:0000313|EMBL:ABB31178.1};
KW Hydrolase {ECO:0000313|EMBL:ABB31178.1};
KW Metal-binding {ECO:0007829|PDB:4H9D};
KW Nuclease {ECO:0000313|EMBL:ABB31178.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007073};
KW Zinc {ECO:0007829|PDB:4H9D}.
FT DOMAIN 27..78
FT /note="HNH nuclease"
FT /evidence="ECO:0000259|SMART:SM00507"
FT BINDING 34
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:4H9D"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:4H9D"
FT BINDING 41
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:4H9D"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:4H9D"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:4H9D"
SQ SEQUENCE 104 AA; 12199 MW; CF485E6CB6C4F6BA CRC64;
MNYFIVEVSE QEVKREKEKA RELRRSQWWK NRIARGICHY CGEIFPPEEL TMDHLVPVVR
GGKSTRGNVV PACKECNNRK KYLLPVEWEE YLDSLESEPS DGEG
//
