ID UBIE_PELCD Reviewed; 237 AA.
AC Q3A209;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Ubiquinone/menaquinone biosynthesis methyltransferase ubiE;
DE EC=2.1.1.163;
DE EC=2.1.1.201;
DE AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE AltName: Full=Demethylmenaquinone methyltransferase;
GN Name=ubiE; OrderedLocusNames=Pcar_2359;
OS Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Pelobacteraceae; Pelobacter.
OX NCBI_TaxID=338963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2380 / Gra Bd 1;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Pelobacter carbinolicus DSM 2380.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
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DR EMBL; CP000142; ABA89598.1; -; Genomic_DNA.
DR RefSeq; YP_006718118.1; NC_007498.2.
DR ProteinModelPortal; Q3A209; -.
DR STRING; 338963.Pcar_2359; -.
DR EnsemblBacteria; ABA89598; ABA89598; Pcar_2359.
DR GeneID; 3725061; -.
DR KEGG; pca:Pcar_2359; -.
DR PATRIC; 22891016; VBIPelCar86875_2548.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249464; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR UniPathway; UPA00079; UER00169.
DR UniPathway; UPA00232; -.
DR GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:HAMAP.
DR GO; GO:0009060; P:aerobic respiration; IEA:HAMAP.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase; Ubiquinone biosynthesis.
FT CHAIN 1 237 Ubiquinone/menaquinone biosynthesis
FT methyltransferase ubiE.
FT /FTId=PRO_1000187784.
SQ SEQUENCE 237 AA; 25893 MW; 48E62F5626C57497 CRC64;
MNKDYRPGQD TRPLFDRIAP RYDLLNRLLS FGIDRRWRLA AVRELALAGA GRILDAATGT
GDVALSIAAA YPRAEVVGVD LSMNMLRAAV PKLLPAEGRI TLLQASCESL PLAAETCDAA
IIAFGIRNVL QRQVALQEFS RVLKPGGRLL VLEFSQPTNP LLAGLYRCYS RHVLPRIGGL
ISDGAAYRYL PDSVEAFPAR GEFLGMMEQS GFRHVRHRDL TGGIVTLYSG CRSLPGD
//
