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Database: UniProt
Entry: Q3A209
LinkDB: Q3A209
Original site: Q3A209 
ID   UBIE_PELCD              Reviewed;         237 AA.
AC   Q3A209;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-SEP-2014, entry version 72.
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
DE            EC=2.1.1.163;
DE            EC=2.1.1.201;
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE   AltName: Full=Demethylmenaquinone methyltransferase;
GN   Name=ubiE; OrderedLocusNames=Pcar_2359;
OS   Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Pelobacteraceae; Pelobacter.
OX   NCBI_TaxID=338963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2380 / Gra Bd 1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Pelobacter carbinolicus DSM 2380.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC       conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC       2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC       trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC       methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family.
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DR   EMBL; CP000142; ABA89598.1; -; Genomic_DNA.
DR   RefSeq; WP_011342120.1; NC_007498.2.
DR   RefSeq; YP_006718118.1; NC_007498.2.
DR   ProteinModelPortal; Q3A209; -.
DR   STRING; 338963.Pcar_2359; -.
DR   EnsemblBacteria; ABA89598; ABA89598; Pcar_2359.
DR   GeneID; 3725061; -.
DR   KEGG; pca:Pcar_2359; -.
DR   PATRIC; 22891016; VBIPelCar86875_2548.
DR   eggNOG; COG2226; -.
DR   HOGENOM; HOG000249464; -.
DR   KO; K03183; -.
DR   OMA; IWKRFTI; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   BioCyc; PCAR338963:GKDU-2602-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases-like.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; Ubiquinone biosynthesis.
FT   CHAIN         1    237       Ubiquinone/menaquinone biosynthesis C-
FT                                methyltransferase UbiE.
FT                                /FTId=PRO_1000187784.
SQ   SEQUENCE   237 AA;  25893 MW;  48E62F5626C57497 CRC64;
     MNKDYRPGQD TRPLFDRIAP RYDLLNRLLS FGIDRRWRLA AVRELALAGA GRILDAATGT
     GDVALSIAAA YPRAEVVGVD LSMNMLRAAV PKLLPAEGRI TLLQASCESL PLAAETCDAA
     IIAFGIRNVL QRQVALQEFS RVLKPGGRLL VLEFSQPTNP LLAGLYRCYS RHVLPRIGGL
     ISDGAAYRYL PDSVEAFPAR GEFLGMMEQS GFRHVRHRDL TGGIVTLYSG CRSLPGD
//
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