ID DDL_PELLD Reviewed; 361 AA.
AC Q3B391;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=D-alanine--D-alanine ligase;
DE EC=6.3.2.4;
DE AltName: Full=D-Ala-D-Ala ligase;
DE AltName: Full=D-alanylalanine synthetase;
GN Name=ddl; OrderedLocusNames=Plut_1331;
OS Pelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM
OS 273)).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC Chlorobium/Pelodictyon group; Pelodictyon.
OX NCBI_TaxID=319225;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 273;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Pelodictyon luteolum DSM 273.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell wall formation (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-
CC alanyl-D-alanine.
CC -!- COFACTOR: Binds 2 magnesium or manganese ions per subunit (By
CC similarity).
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR EMBL; CP000096; ABB24190.1; -; Genomic_DNA.
DR RefSeq; YP_375233.1; NC_007512.1.
DR ProteinModelPortal; Q3B391; -.
DR STRING; 319225.Plut_1331; -.
DR EnsemblBacteria; ABB24190; ABB24190; Plut_1331.
DR GeneID; 3744483; -.
DR KEGG; plt:Plut_1331; -.
DR PATRIC; 21380284; VBIChlLut1287_1401.
DR eggNOG; COG1181; -.
DR HOGENOM; HOG000011593; -.
DR KO; K01921; -.
DR OMA; LLHGPFG; -.
DR ProtClustDB; PRK01966; -.
DR BioCyc; PLUT319225:GHDM-1352-MONOMER; -.
DR UniPathway; UPA00219; -.
DR GO; GO:0005618; C:cell wall; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 2.
DR Gene3D; 3.40.50.20; -; 1.
DR HAMAP; MF_00047; Dala_Dala_lig; 1; -.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR000291; D-Ala_lig_Van_CS.
DR InterPro; IPR005905; D_ala_D_ala.
DR InterPro; IPR011095; Dala_Dala_lig_C.
DR InterPro; IPR011127; Dala_Dala_lig_N.
DR InterPro; IPR016185; PreATP-grasp_dom.
DR PANTHER; PTHR23132; PTHR23132; 1.
DR Pfam; PF07478; Dala_Dala_lig_C; 1.
DR Pfam; PF01820; Dala_Dala_lig_N; 1.
DR SUPFAM; SSF52440; PreATP-grasp-like; 1.
DR TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
DR PROSITE; PS00844; DALA_DALA_LIGASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell shape; Cell wall biogenesis/degradation;
KW Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
FT CHAIN 1 361 D-alanine--D-alanine ligase.
FT /FTId=PRO_1000030477.
FT DOMAIN 144 350 ATP-grasp.
FT NP_BIND 177 232 ATP (By similarity).
FT METAL 303 303 Magnesium or manganese 1 (By similarity).
FT METAL 317 317 Magnesium or manganese 1 (By similarity).
FT METAL 317 317 Magnesium or manganese 2 (By similarity).
FT METAL 319 319 Magnesium or manganese 2 (By similarity).
SQ SEQUENCE 361 AA; 38707 MW; B3EB96E244C0ED90 CRC64;
MHHTTVALLF GGRSLEHEIS VISARAVAAN IDRDRYRVLA VYITRDGGWY AGGVAEQILK
LDIADLIRTT SLEATAATLR EMVAASAEPP FNFDFRGIDV AFPVLHGSYG EDGRVQGLLE
TLQVPCTGCG VLASALTMDK ALTKLAAADA GLAVAVSVTV MSHAYRRDPE ATHRLAVASL
SFPMFVKPVS LGSSVGITKV NSESELAEAI THACSLDSKV LIEQAVKGRE VEVAVIGNDT
LEASPCGEIE PGSEFYDYED KYIHDTAKLF IPARIPGDLQ EKVREAALCA YRALGCRGMS
RVDFFVDETT GSIVFNEINT IPGFTPVSMY PRLMAAAGTG FMELTDRLIR LAMEPEAGAS
A
//
