GenomeNet

Database: UniProt
Entry: Q3BMA4
LinkDB: Q3BMA4
Original site: Q3BMA4 
ID   PYRF_XANC5              Reviewed;         243 AA.
AC   Q3BMA4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   14-MAY-2014, entry version 59.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE            EC=4.1.1.23;
DE   AltName: Full=OMP decarboxylase;
DE            Short=OMPDCase;
DE            Short=OMPdecase;
GN   Name=pyrF; OrderedLocusNames=XCV4378;
OS   Xanthomonas campestris pv. vesicatoria (strain 85-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=316273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=85-10;
RX   PubMed=16237009; DOI=10.1128/JB.187.21.7254-7266.2005;
RA   Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D.,
RA   Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C.,
RA   Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H.,
RA   Niesbach-Kloesgen U., Patschkowski T., Rueckert C., Rupp O.,
RA   Schneiker S., Schuster S.C., Vorhoelter F.J., Weber E., Puehler A.,
RA   Bonas U., Bartels D., Kaiser O.;
RT   "Insights into genome plasticity and pathogenicity of the plant
RT   pathogenic Bacterium Xanthomonas campestris pv. vesicatoria revealed
RT   by the complete genome sequence.";
RL   J. Bacteriol. 187:7254-7266(2005).
CC   -!- FUNCTION: Catalyzes the decarboxylation of orotidine 5'-
CC       monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from orotate: step 2/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 1
CC       subfamily.
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DR   EMBL; AM039952; CAJ26109.1; -; Genomic_DNA.
DR   RefSeq; YP_366109.1; NC_007508.1.
DR   ProteinModelPortal; Q3BMA4; -.
DR   STRING; 316273.XCV4378; -.
DR   EnsemblBacteria; CAJ26109; CAJ26109; XCV4378.
DR   GeneID; 3732791; -.
DR   KEGG; xcv:XCV4378; -.
DR   PATRIC; 24098436; VBIXanCam71633_4678.
DR   eggNOG; COG0284; -.
DR   HOGENOM; HOG000226070; -.
DR   KO; K01591; -.
DR   OMA; RPITQSA; -.
DR   OrthoDB; EOG6N6815; -.
DR   BioCyc; XCAM316273:GJF8-4492-MONOMER; -.
DR   UniPathway; UPA00070; UER00120.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01200_B; OMPdecase_type1_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014732; OMPdecase.
DR   InterPro; IPR018089; OMPdecase_AS.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR01740; pyrF; 1.
DR   PROSITE; PS00156; OMPDECASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Decarboxylase; Lyase; Pyrimidine biosynthesis.
FT   CHAIN         1    243       Orotidine 5'-phosphate decarboxylase.
FT                                /FTId=PRO_0000241931.
FT   REGION       69     78       Substrate binding (By similarity).
FT   ACT_SITE     71     71       Proton donor (By similarity).
FT   BINDING      19     19       Substrate (By similarity).
FT   BINDING      41     41       Substrate (By similarity).
FT   BINDING     124    124       Substrate (By similarity).
FT   BINDING     185    185       Substrate (By similarity).
FT   BINDING     194    194       Substrate (By similarity).
FT   BINDING     214    214       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     215    215       Substrate (By similarity).
SQ   SEQUENCE   243 AA;  25692 MW;  E49BC68570A372B1 CRC64;
     MSRAPLPLAA HERLIFALDV PGHDEAIAWV DRLGDSVSFY KIGMELLASG EYFHVLDALA
     KRDKRVFVDL KFFDIPATVA GTIRRLAQWP VSYCTVHGWH AGMLQAAAEA NHGDMRLLAV
     TVLTSMGRPD LAAMGIDREP VDVVVERALA AQAAGIDGVI ASGQEAGPIR RATGPDFSIV
     CPGIRPGGPV GDDQQRTVGV AQAFTDGADA IVVGRPIRQA SDPAAAATAI QDEIRAALPQ
     NGN
//
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