ID Q3I7D1_MONPV Unreviewed; 354 AA.
AC Q3I7D1;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Soluble interferon alpha/beta receptor OPG204 {ECO:0000256|ARBA:ARBA00041012};
GN ORFNames=MPXV_USA2003_039_192 {ECO:0000313|EMBL:AAY97783.1},
GN MPXV_USA2003_044_192 {ECO:0000313|EMBL:AAY96985.1};
OS Monkeypox virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10244 {ECO:0000313|EMBL:AAY97783.1, ECO:0000313|Proteomes:UP000141425};
OH NCBI_TaxID=45479; Cynomys gunnisoni (Gunnison's prairie dog) (Spermophilus gunnisoni).
OH NCBI_TaxID=99825; Cynomys leucurus (White-tailed prairie dog).
OH NCBI_TaxID=45480; Cynomys ludovicianus (Black-tailed prairie dog).
OH NCBI_TaxID=99826; Cynomys mexicanus (Mexican prairie dog).
OH NCBI_TaxID=99827; Cynomys parvidens (Utah prairie dog).
OH NCBI_TaxID=30650; Gliridae (dormice).
OH NCBI_TaxID=226685; Heliosciurus ruwenzorii (Ruwenzori sun squirrel).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
RN [1] {ECO:0000313|Proteomes:UP000141425, ECO:0000313|Proteomes:UP000151594}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA_2003_039 {ECO:0000313|EMBL:AAY97783.1}, and USA_2003_044
RC {ECO:0000313|EMBL:AAY96985.1};
RX PubMed=16186219; DOI=10.1099/vir.0.81215-0;
RA Likos A.M., Sammons S.A., Olson V.A., Frace A.M., Li Y.,
RA Olsen-Rasmussen M., Davidson W., Galloway R., Khristova M.L.,
RA Reynolds M.G., Zhao H., Carroll D.S., Curns A., Formenty P., Esposito J.J.,
RA Regnery R.L., Damon I.K.;
RT "A tale of two clades: monkeypox viruses.";
RL J. Gen. Virol. 86:2661-2672(2005).
CC -!- SUBUNIT: Interacts with host IFNA1. {ECO:0000256|ARBA:ARBA00038761}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; DQ011153; AAY96985.1; -; Genomic_DNA.
DR EMBL; DQ011157; AAY97783.1; -; Genomic_DNA.
DR SMR; Q3I7D1; -.
DR Proteomes; UP000141425; Genome.
DR Proteomes; UP000151594; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF44; X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Receptor {ECO:0000313|EMBL:AAY97783.1};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 158..240
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 249..348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 354 AA; 41122 MW; 4E08C0C44F527A24 CRC64;
MMKMKMKMMV RIYFVSLSLL LFHSYAIDIE NEITEFFNKM RDTLPAKDSK WLNPVCMFGG
TMNDMAALGE PFSAKCPPIE DSLLSHRYKD YVVKWERLEK NRRRQVSNKR VKHGDLWIAN
YTSKFSNRRY LCTVTTKNGD CVQGVVRSHV WKPSSCIPKT YELGTYDKYG IDLYCGILYA
KHYNNITWYK DNKEINIDDF KYSQAGKELI IHNPELEDSG RYDCYVHYDD VRIKNDIVVS
RCKILTVIPS QDHRFKLILD PKINVTIGEP ANITCSAVST SLFVDDVLIE WKNPSGWIIG
LDFGVYSILT SRGGITEATL YFENVTEEYI GNTYTCRGYN YYFDKTLTTT VVLE
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