ID Q3JKQ1_BURP1 Unreviewed; 6072 AA.
AC Q3JKQ1;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN Name=sypC {ECO:0000313|EMBL:ABA52818.1};
GN OrderedLocusNames=BURPS1710b_A0693 {ECO:0000313|EMBL:ABA52818.1};
OS Burkholderia pseudomallei (strain 1710b).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=320372 {ECO:0000313|EMBL:ABA52818.1, ECO:0000313|Proteomes:UP000002700};
RN [1] {ECO:0000313|EMBL:ABA52818.1, ECO:0000313|Proteomes:UP000002700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1710b {ECO:0000313|EMBL:ABA52818.1,
RC ECO:0000313|Proteomes:UP000002700};
RA Woods D.E., Nierman W.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP000125; ABA52818.1; -; Genomic_DNA.
DR RefSeq; WP_011326190.1; NC_007435.1.
DR ESTHER; burma-q62ar2.1; Thioesterase.
DR ESTHER; burma-q62ar2.2; Thioesterase.
DR EnsemblBacteria; ABA52818; ABA52818; BURPS1710b_A0693.
DR KEGG; bpm:BURPS1710b_A0693; -.
DR HOGENOM; CLU_222916_0_0_4; -.
DR Proteomes; UP000002700; Chromosome II.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd12116; A_NRPS_Ta1_like; 1.
DR CDD; cd19544; E-C_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 10.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 1.10.10.1830; Non-ribosomal peptide synthase, adenylation domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR044894; TubC_N_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF00975; Thioesterase; 2.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1098..1173
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2214..2289
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3306..3380
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4379..4454
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5437..5512
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2101..2126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3205..3233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3207..3233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6072 AA; 661516 MW; BCB21A6EFB44A1E1 CRC64;
MTANDLLALL NSKGIALSVK GDNLAITGDE KVLEDPGLLA LLRANKPALI DLIKDGHGTV
GGAVRVPPNR IPADAERIAP EQLTLVRLDQ GEIDALVARV DGGAANVQDI YPLVPMQEGM
LFHHLLSQQG DAYLESYLLA FRTRERLDRF LSALQQVIDR HDILRTAFFW EGLPHSVQVV
QRRATLPLNV VELDPRDGDV GQQLEARYDP RSHRIDVGRA PLMQVHAAHD AAGGRWLVRL
LSHHLAVDHT TLERVIEEAR AIGQGRAEDL PRPEPFRNFV AQARLGVSEA DHEAYFRARL
GDIDEPTAPF GLLSVQGDGR EIAEAARRLK PELSGALRGH ARRLGVSAAS MMHVAWGLVL
SRTTGRQDVV FGTVLFGRMQ GGAQSDRALG LFINTLPVRM RVAQTGVEAS VKETHAQLAE
LMRHEHAPLV LAQRCSGVPA QTPLFTSLLN YRYGLRHCAD AATPGGDDIE LLSARERTNY
PLTLSVDDLG QDFSLTVQVS GHVDPQRVCA FMETALEQLA QALGKQPQCD IGGLDVLPRS
EREQMVYAWN ATERDYPIEQ CIHQLFEAQV DRKPEAIALT FDGRRLSYAE LNARANRLAH
YLQARGVGPD RLVALCAERG IEMVVGLLAI LKAGGAYVPL DPAYASDRLR GIVEDSQPAL
VLADAVGRAA LGELDGALPV IDPETDALRW REMPATNPEV ASQHVHHLAY VIYTSGSTGR
PKGVMVEHAQ VVRLFGATQA WFGFDERDVW TLFHSYGFDF SVWELWGALL HGGRLVIVPT
EVTRTPSAFF ALLCAEGVTV LNQTPSAFQA LMSAQEEREE AAGNIERANV IAHRLRYVIF
GGEALEPRTL ASWYARHGER TQLVNMYGIT ETTVHVTYCA LRAEDAMRLG ASPIGVRIPD
LQLYVLDARR EPVPMGVTGE LYVGGAGVAR GYLNRPELTR ERFIDDPFVA GGRLYKTGDL
ARWRTDGSLE YLGRNDFQVK IRGFRIELGE IEAQLAKVTG VREVVVLARD SAADTDQNAD
PNASATANSS EKRLVAYYTG DADVAALRAQ AAQHLPSYMV PSAYVRLDAW PLTPNGKLDR
RALPAPADDA YARAEYEAPQ GAKEEALAVI WRELLHVERV SRHDNFFELG GHSLLAVQLV
SRLRQALSVE VALSTVFDAP VLSALAERLE AENTAVLPPI PLASRDGRIA LSLAQQRLWF
LTQLEGVSEA YHMSGAVRLD GPLNREVLQR ALNRIVMRHE ALRTCFAREE GEPIQVIQPH
ADLTVSYHDL REAEQTEQRA KDLSQAHASA PFDLSRDLPV RVLLLQLADE AHVVQVVMHH
IASDGWSVGV FLQELSALYG SFIAEQGDPL APLPLQYADY AAWQRRWLAS GQLEKQGAFW
QTNLSGAPTL LELPTDRPRP PKQSHAGASV EVKLGAALSE RVKRLSQRHG VTPYMTLLSS
WAAVLSRLSG QEEVVIGSPV AGRNRTEVEA LIGFFVNTLA LRLDLSSEPT VGELLKRTKA
QVLSAQAHQD LPFDQVVERV KPPRSTAHPP LFQVMFVWQN MPAGELTIPG LTIRAVETPL
QTAQFELTLS LQEAGDDIVG HLNYASALFD ESTVRRYVTY WRRLLEGMTA GAADQTIVGL
PLLDEAERKQ VVYEWNATER DYPIEQCIHQ LFEAQVDRKP EAIALTFEGQ RLSYAELNAR
ANRLAHYLQG RGVGPDRLVA LCAERGIEMV VGLLAILKAG GAYVPLDPAY ASDRLRGIVE
DSQPALVLAD AVGRAALGEL DGALPVIDPE TDALRWREMP ATNPEVASQH VHHLAYVIYT
SGSTGRPKGV MVEHAQVVRL FGATQAWFGF DERDVWTLFH SYGFDFSVWE MWGALLHGGR
LVIVPTEVTR TPSAFFALLC AEGVTVLNQT PSAFQALMSA QEEREEAAGN IERANVIAHR
LRYVIFGGEA LEPRTLASWY ARHGERTQLV NMYGITETTV HVTYCALRAE DAMRLGASPI
GVRIPDLQLY VLDDRREPVP MGVTGELYVG GAGVARGYLN RPELTRERFI DDPFVAGGRL
YRTGDLARWR TDGRLEYLGR NDFQVKIRGF RIELGEIEAQ LAKVAGVREV VVLARDSAAE
VRDSATEHAT PNALSPSPET STATATATAA ATAAATATAT ATATAPEKRL VAYYTGDADV
TALRAQAAQN LPSYMVPSAY VRLDAWPLTP NGKLDRRALP APADDAYARA EYEAPQGAKE
EALAAIWREL LHVERVSRHD NFFELGGHSL LAVQLVSRLR QALSVEVALG TVFDAPVLSA
LAERLEAENT EVLPPIPLAP RDGRIALSLA QQRLWFLTQL EGVSEAYHMS GAVRLDGPLN
REVLQRALNR IVMRHEALRT CFAREEGEPI QVIQPHADLT MSYHDLREAE SIRHEAGNRE
QRAKDLSQAH ASAPFDLSRD LPVRVLLLQL ADEAHVVQVV MHHIASDGWS VGVFLQELSA
LYGSFIAEQG DPLAPLPLQY ADYAAWQRRW LASGQLEKQG AFWQTNLSGA PTLLELPTDR
PRPPKQLHAG ASVEVKLGAA LSERVKRLSQ RHGVTPYMTL LSSWAAVLSR LSGQEEVVIG
SPVAGRNRTE VEALIGFFVN TLALRLDLSS EPTVGELLKR TKAQVLSAQA HQDLPFDQVV
ERVKPPRSTA HPPLFQVMFV WQNAHEGSLQ IPGLRLSTWG DPLTMAPFEL TLAVREHQDD
IACTLTYATS LFDRATVERY LGHWLRQLDA MATDADPVVT GLPLLGEAER AQVLHGWNET
GRAYARDACL HQLFEAQVSR TPEAAAVICG DETLSYTDLD ARANRLAHYL RGQGVGPDTR
VGLALGRGVE MMTGLLAVLK AGGAYVPLDP GYASERLRAI LDDSRPAIVL ADAAGRTALD
ALAGAPPIAD LHADASRWSA LPSTPPRVEG LTPRHLAYVI YTSGSTGQPK GVMVEHASVV
NLWRALDEAI YRTHPSARRV SLNASIAFDS LVKQWVQLLS GRTLVVVPEP VRFDGRRLLD
AIGRDRIDVF DCTPSQLALI EGARGPEDEA YPQVTLVGGE AIGEGMWSEL ASASSRTYYN
VYGPTECTVD ATLARITAEH APHIGGPLAN VRAYVLNERL SPAPVGVRGE LYIGGAGVAR
GYLNRPELTR ERFIDDPFVA GGRLYRTGDL ARWRTDGRLE YLGRNDFQVK IRGFRIELGE
IEAQLAKVTG VREVVVLARD SASAVHDSAT EHATPNALSP SPETSTATAT ATATATATEK
RLVAYYKGDA DVAALRAQAA QHLPSYMVPS AYVRLDAWPL TPNGKLDRRA LPAPADDAYA
RAEYEAPQGA KEEALAEIWR DLLQVDQISR HDNFFQLGGH SLLAISLGDM MRERGLHADV
RTLFNAETLA ALAAQSGTDS IDVDVPPNLI PVGAARITPD MLPLVALTQP QIDAIAQQVD
GGATNVQDIY PLAPLQEGML FHHLLHTQGD LYLEPHLLAF RTRERLERFL SALQCVIDRH
DVLRTGFFWE GVPQPVQVVW RRARLPVEYV ELPDSHGDVA SQLEARCDPR RHRIDIGRAP
LVHCHVAHDA RNDRWVLGVL THHLVSDHTT LALLAEEAQA FEQGRGDALP PAVPFRNFVA
HARLGTSERE HEAFFREMLG DVDEPTAPFG LLDVQGDGSA IVEHRRALAP GLSRSVRAHA
RRLGVSAASV MHVAWSLVLA RTANRRDVVF GTVLFGRMQG GAHAHRTMGL FMNTLPVRIA
LDESDVETSL IATHDRLARL LRHEHAPLAL AQRCSAVPAQ APLFTSLLNY RYSPHEEQGD
ATDDDVQFIA ARERNNYPLT MIVDDTGEGF ALTAQVDASI DAARVCAFMH TALEQLVRAL
DDARGAVLAE LDVLPADEHR CVVSACNDTD AELPGVDFVD RRFEAQAART PEAIAVACGA
HALSYAALNR RANRLAHYLR AHGAGPERVV ALALERSVDM MVGLLGILKS GSAYLPLDPA
YPAERLAYIV DDARPALLLT EAARRDDWRD AGVPVVLLDA DGPAIDACPD HNPDAAAGRD
ARTLSSLAYV IYTSGSTGRP KGVMIEHRNL ANLLGAMGEQ PGIGAHDVLL AVTSLSFDIA
ALELFLPLLH GARAVIAARD DAADPARLAH LIESSGASLM QATPSTWRML AQHGWPRSAR
PLTLLCGGEA LPPALAERLL AHVPAIWNLY GPTETTVWST VRRVTTPVVD IGGPLANTQV
YVLDERLRPA PIGVAGELYI GGAGVARGYL NRPELTRERF VDDPFRRGGR LYRTGDLARR
RADGNLEYLG RNDFQVKIRG FRIELGEIEA QLAKAHGVQG VALAARDTPT ADKRLVAYYV
GDASAAALRE HAAARLPAYM VPAAYVRLAA WPLTPNGKLD RAALPAPDDE AYARAEYEAP
RGEHECKLAA IWRAVLQVER IGRHDDFFEL GGHSLLAVRA VTAMRDAFGS DTSLRDLFAR
PVLKDLAEHA STAARARDAA IPKAARGEPV PMSFAQQRLW FLARMGGLGD AYHMPIAVRL
HGALDVDALQ RALSRIVSRH DALRTTFALE GEQPVQRVHA DDGAGLRLRI DDLRGCADAG
ARRARILAGQ ASEPFDLARG PLVRGALVRE ADDVHTLCVT IHHIVSDGWS IDVFRRELSE
LYRAFAGGRP DPLPPLPVQY ADYAAWQQRG IGGAALHAQA EYWRDALAGA PTLLELPTDR
PRPPQPDYAG ATVGLALDAP LTAGLRALAR RHGATLFMTV FAAWSVLLSR LSRQTDVVIG
TPSANRGHAQ IEGLIGFFVN TIALRVDLDG APTVAELLAR VKARTLAAQQ HQDIPFEHVV
ERVQPARSLS HSPVFQAMFA WQHASRGEMR LEGLRAEPLD DAARTIAKFD LTLSLRESGD
AIDGGLEYAS ALFERATIER FAGYLRRLLE GMVADDTQRV DALPMLSRDE RRDLIERRNA
TARPYPANSG VHRLFEAQAA RTPDATAIVD GATTLDYRAL DARANRIAHA LAHAGVRAGD
RVALHLEPSI GLVAAQLAVL KLGAAYVPVD VGNPPARKAF VAQDSGARLV LGDAALDWPA
AAGVPQRDLA ALLAGPWPSD APARAPQCGG DTPAYVMYTS GSSGQPKGVL VTHRGIARLA
VNSGYATFDA SDRFAFASNP AFDASTFEVW TALLNGASIG IVKRDDLLDL GALAGKLSSI
GVTCLFLTTA LFNRCVSFDP AMFARLRCVI SGGERADPAV YRKVLEAGPP RHLLNAYGPT
ETTTFAAVWE AEPRTLAAQA APIGRPIGNT SVYVLDAYGA PVPVGVTGEI HIGGPGVAQG
YLNRPALSAE RFVRDPFVGG DARMYRTGDL GRWRPDGMLD CIGRADFQVK IRGFRIELGE
IEACLLEHGA LAQAAVLARD DGGDGGKTLV AYYVPRAGHE DGAPALRAHL AARLPEYMVP
AAYVRLPAMP LTPNGKLERR ALPAPDERSY VRRDYAAPQG EIETTLARIW AELFGIERVG
RHDGFFELGG HSLLAVRMVA RVHDVLGVEV PLRALFADPV LHVFASAVAR ASTRQASSNL
VAFRSAGTAA PLFFIHSGLG EIGFVGDLLP GIAPEIPVYG FAAVGFLAGE TPHATIEEMA
AQYVDAMRRV QPHGPYRLAG WCAGGNIAFE MAHQLIAADE TVEFLCMIDS PTSAPIDRSV
TACVLARIPD DIPEALRTRL HALGDAFDVR GMLHACQAAG MLPIDLPTGL MERHVAVQYA
IKHAKLNYVP PRLPVDVIHF VAQDEPMWRN GWAMDGWHDV ADRVICLPAS GDHMTMVAAP
HAEQLGRRIT EALAVHGGPR ADGAECGYAP RIAIQTAPRD ARAPTLFCIP GAGASVTTFS
TLARHLPATF SVDGLQPRGL CGTMVPYLDV ETAARAYLRS IRKAAPRGPY HLVGHSFGGW
VAYEIACRLQ EQGERVATLM LLDTERPGAT DIVRGRKTRV DALAKLVELY EMHLGRPLGV
SRDDLAALAH DAQIEHLRAA LVRAKILPPS VHPNVLLGVV RVLEMNVNTP YRPAGLYAGT
MHVVLIANAK ADADLDAWRD EQAEQWRGLA DDVRIVRAGG NHMTMLQPPH AASIAALLER
TAGAPARLAQ VH
//
