ID Q3JWU6_BURP1 Unreviewed; 311 AA.
AC Q3JWU6;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=hydroxymethylglutaryl-CoA lyase {ECO:0000256|ARBA:ARBA00012910};
DE EC=4.1.3.4 {ECO:0000256|ARBA:ARBA00012910};
GN OrderedLocusNames=BURPS1710b_0543 {ECO:0000313|EMBL:ABA47965.1};
OS Burkholderia pseudomallei (strain 1710b).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=320372 {ECO:0000313|EMBL:ABA47965.1, ECO:0000313|Proteomes:UP000002700};
RN [1] {ECO:0000313|EMBL:ABA47965.1, ECO:0000313|Proteomes:UP000002700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1710b {ECO:0000313|EMBL:ABA47965.1,
RC ECO:0000313|Proteomes:UP000002700};
RA Woods D.E., Nierman W.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA;
CC Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57288; EC=4.1.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001651};
CC -!- PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-
CC methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-
CC methylglutaryl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00005143}.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; CP000124; ABA47965.1; -; Genomic_DNA.
DR RefSeq; WP_004522997.1; NC_007434.1.
DR AlphaFoldDB; Q3JWU6; -.
DR EnsemblBacteria; ABA47965; ABA47965; BURPS1710b_0543.
DR GeneID; 56527423; -.
DR KEGG; bpm:BURPS1710b_0543; -.
DR HOGENOM; CLU_022138_3_2_4; -.
DR UniPathway; UPA00896; UER00863.
DR Proteomes; UP000002700; Chromosome I.
DR GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000138; HMG_CoA_lyase_AS.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS01062; HMG_COA_LYASE; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:ABA47965.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 7..274
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 311 AA; 32434 MW; AEBF65508A100A60 CRC64;
MTLPQSVKIV EVGPRDGLQN EQTFVPTGVK IELVNRLSQA GFRNVEAASF VSPKWVPQMA
DGADVMAGIA RRAGTIYSAL TPNLKGVENA LAARADEVVI FGAASEAFSR RNINCSIAES
IARFEPVARA AKDAGVRLRA SVSCALGCPY QGDVPLEAVV DVVERLAALG CDEIDIADTI
GVGTPGRTRA VLDAVAKAFP RERLSGHFHD TYGQALANIY AALLEGIAIF HASVAGLGGC
PYAKGATGNV ATEDVLYMMR GLNIETGVDL DQVVAAGDFI SNAIGRANIS RAGRALLAKQ
RAAAEPPSAC A
//
