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Database: UniProt
Entry: Q3KH85
LinkDB: Q3KH85
Original site: Q3KH85 
ID   TRUD_PSEPF              Reviewed;         352 AA.
AC   Q3KH85;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   14-MAY-2014, entry version 54.
DE   RecName: Full=tRNA pseudouridine synthase D;
DE            EC=5.4.99.27;
DE   AltName: Full=tRNA pseudouridine(13) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase D;
DE   AltName: Full=tRNA-uridine isomerase D;
GN   Name=truD; OrderedLocusNames=Pfl01_1128;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       13 in transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(13) = tRNA pseudouridine(13).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
CC   -!- SIMILARITY: Contains 1 TRUD domain.
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DR   EMBL; CP000094; ABA72871.1; -; Genomic_DNA.
DR   RefSeq; YP_346860.1; NC_007492.2.
DR   ProteinModelPortal; Q3KH85; -.
DR   STRING; 205922.Pfl01_1128; -.
DR   EnsemblBacteria; ABA72871; ABA72871; Pfl01_1128.
DR   GeneID; 3716552; -.
DR   KEGG; pfo:Pfl01_1128; -.
DR   PATRIC; 19884349; VBIPseFlu44242_1151.
DR   eggNOG; COG0585; -.
DR   HOGENOM; HOG000224848; -.
DR   KO; K06176; -.
DR   OMA; ALTRQWF; -.
DR   OrthoDB; EOG6FRCSP; -.
DR   BioCyc; PFLU205922:GJBD-1147-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01082; TruD; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001656; PsdUridine_synth_TruD.
DR   InterPro; IPR020119; PsdUridine_synth_TruD_CS.
DR   InterPro; IPR011760; PsdUridine_synth_TruD_insert.
DR   PANTHER; PTHR13326; PTHR13326; 1.
DR   Pfam; PF01142; TruD; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS50984; TRUD; 1.
DR   PROSITE; PS01268; UPF0024; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    352       tRNA pseudouridine synthase D.
FT                                /FTId=PRO_0000230146.
FT   DOMAIN      157    303       TRUD.
FT   ACT_SITE     81     81       Nucleophile (By similarity).
SQ   SEQUENCE   352 AA;  38769 MW;  DB94978FFD910E42 CRC64;
     MNELQLLGPR AYGDALGTAV LKAIAEDFQV DEVLDIPFSG DGEHLWIWVE KRGLNTEEAA
     RRIAKAAGVP LRTVSYAGLK DRQALTRQWF SVQLPGKADP DLSAAENDTL KILKTTRHKR
     KLQRGAHSAN GFTLRLTQFN GDKAAIDERL QLIAKQGIPN YFGAQRFGHD GGNVVDARSW
     AARKALPEQR NVRSRLLSTA RSFLFNQVLA ARVADGTWQR AQVGDLLAFT DSRSFFPAGE
     AECSDPRLAI LDLHPTGPQW GEGDSPAAGV VHDLEQGIAA READLRDWLI NAGMSHERRI
     LRLPIGGLTW HYPEPDILQL EFVLPAGCFA TVLVRELVDL VPVGQTDSPC VF
//
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