ID Q3SLE8_THIDA Unreviewed; 490 AA.
AC Q3SLE8;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Putative modulator of DNA gyrase {ECO:0000313|EMBL:AAZ96465.1};
GN OrderedLocusNames=Tbd_0512 {ECO:0000313|EMBL:AAZ96465.1};
OS Thiobacillus denitrificans (strain ATCC 25259).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Thiobacillaceae; Thiobacillus.
OX NCBI_TaxID=292415 {ECO:0000313|EMBL:AAZ96465.1, ECO:0000313|Proteomes:UP000008291};
RN [1] {ECO:0000313|EMBL:AAZ96465.1, ECO:0000313|Proteomes:UP000008291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25259 {ECO:0000313|EMBL:AAZ96465.1,
RC ECO:0000313|Proteomes:UP000008291};
RX PubMed=16452431; DOI=10.1128/JB.188.4.1473-1488.2006;
RA Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT anaerobic bacterium Thiobacillus denitrificans.";
RL J. Bacteriol. 188:1473-1488(2006).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP000116; AAZ96465.1; -; Genomic_DNA.
DR RefSeq; WP_011311024.1; NC_007404.1.
DR AlphaFoldDB; Q3SLE8; -.
DR STRING; 292415.Tbd_0512; -.
DR KEGG; tbd:Tbd_0512; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_4; -.
DR OrthoDB; 9803213at2; -.
DR Proteomes; UP000008291; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008291}.
FT DOMAIN 50..114
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 139..247
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 255..488
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 490 AA; 52186 MW; A66AE4B534BB383E CRC64;
MNPTDAFVPI QSAEQLFRSA EATLLTPNGL DADKLAPVFG RLLTHDVDYA DLYFQYSRSE
GWSLEEGQVK SGSFNIDQGV GVRAICGEKT AFAYSDDISL DALGAAADAT RAIARAGQNR
SFGMVHRGEG RLLYNAVDPL VSLDDAAKVA LLERLEKKAR AMDPRVIQVM ASLASEYEVV
FIARSDGHLA ADVRPLVRLS LQVIAEQDGR REQGSGGGGG RFDYSYFTDD ILEKYARQAV
HQASVNLEAR PAPAGSMTVV LGAGWPGILL HEAIGHGLEG DFNRKGSSAF SGRIGERVAA
PGVTVVDDGT IPLRRGSLNV DDEGNPTQRT TLIEDGVLTG YMQDMMNARL MGMQPTGNAR
RESFAHLTMP RMTNTLMLGG DKHPHEIIAS VKNGLYAVNF GGGQVDITSG KFVFSAAEAY
MIENGKISYP VKGATLIGNG PEVLTRVSMI GNDMEMDSGV GTCGKEGQSV PVGVGQPTLR
IDGLTVGGTA
//
