ID Q3T2X1_9HIV1 Unreviewed; 335 AA.
AC Q3T2X1;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAX97141.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAX97141.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAX97141.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=02TZ_HS123.7e28 {ECO:0000313|EMBL:AAX97141.1};
RX PubMed=16140747; DOI=10.1128/JVI.79.18.11693-11704.2005;
RA McCutchan F.E., Hoelscher M., Tovanabutra S., Piyasirisilp S.,
RA Sanders-Buell E., Ramos G., Jagodzinski L., Polonis V., Maboko L.,
RA Mmbando D., Hoffmann O., Riedner G., von Sonnenburg F., Robb M., Birx D.L.;
RT "In-depth analysis of a heterosexually acquired human immunodeficiency
RT virus type 1 superinfection: evolution, temporal fluctuation, and
RT intercompartment dynamics from the seronegative window period through 30
RT months postinfection.";
RL J. Virol. 79:11693-11704(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY887472; AAX97141.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAX97141.1};
KW Virion {ECO:0000313|EMBL:AAX97141.1}.
FT TRANSMEM 157..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..197
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX97141.1"
SQ SEQUENCE 335 AA; 38601 MW; D420A7C19F2ABFC1 CRC64;
FLGAAGSTMG AASLTLTVQA RQLLTGIVQQ QSNLLRAIEA QQHLLKLTVW GIKQLQARVL
AVERYLKDQQ LLGIWGCSGK LICTTNVPWN SSWSNKSFND IWDNMTWLQW DKEISNYTEI
IYNLIEESQN QQEKNELDLL ALDKWAGLWN WFDITNWLWY IKIFIMIVGG LIGLRIVFTV
LSIINRVRQG YSPLSFQIHT PNPRGPDRLG RIEEEGGEQG RDRSIRLVSG FLALAWDDLR
SLCLFSYHRL RDLILIATRI VELLGRRGWE AIKYLWNLLK YWIQELKNSA ISLLNTTAIA
VAEGTDRIIE VVQRAGRIVL NIPRRIRQGF ERALL
//
