ID Q3U1J9_MOUSE Unreviewed; 1074 AA.
AC Q3U1J9;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 141.
DE SubName: Full=Elastin microfibril interfacer 2 {ECO:0000313|EMBL:ACX47082.1};
GN Name=Emilin2 {ECO:0000313|MGI:MGI:2389136};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE33498.1};
RN [1] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE33498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE33498.1}, and NOD
RC {ECO:0000313|EMBL:BAE32450.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [10] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [11] {ECO:0000313|EMBL:ACX47082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:ACX47082.1};
RX PubMed=20700597; DOI=10.1007/s00335-010-9274-6;
RA Sa Q., Hart E., Nadeau J.H., Hoover-Plow J.L.;
RT "Mouse chromosome 17 candidate modifier genes for thrombosis.";
RL Mamm. Genome 21:337-349(2010).
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DR EMBL; GQ872460; ACX47082.1; -; mRNA.
DR EMBL; AK154230; BAE32450.1; -; mRNA.
DR EMBL; AK155909; BAE33498.1; -; mRNA.
DR EMBL; AK155913; BAE33501.1; -; mRNA.
DR EMBL; AK170822; BAE42053.1; -; mRNA.
DR EMBL; AK170953; BAE42136.1; -; mRNA.
DR EMBL; AK171015; BAE42186.1; -; mRNA.
DR EMBL; AK171020; BAE42190.1; -; mRNA.
DR EMBL; AK171592; BAE42548.1; -; mRNA.
DR RefSeq; NP_660140.1; NM_145158.3.
DR AlphaFoldDB; Q3U1J9; -.
DR SMR; Q3U1J9; -.
DR Antibodypedia; 21912; 68 antibodies from 17 providers.
DR GeneID; 246707; -.
DR KEGG; mmu:246707; -.
DR AGR; MGI:2389136; -.
DR CTD; 84034; -.
DR MGI; MGI:2389136; Emilin2.
DR VEuPathDB; HostDB:ENSMUSG00000024053; -.
DR HOGENOM; CLU_011705_0_0_1; -.
DR OMA; PAWPGWT; -.
DR OrthoDB; 5349070at2759; -.
DR BioGRID-ORCS; 246707; 3 hits in 79 CRISPR screens.
DR ChiTaRS; Emilin2; mouse.
DR ExpressionAtlas; Q3U1J9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; IEA:Ensembl.
DR GO; GO:1901731; P:positive regulation of platelet aggregation; IEA:Ensembl.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1074
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014309130"
FT DOMAIN 47..123
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 922..1073
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 121..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 264..305
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 146..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..853
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 117310 MW; 4B81728C83CE52A7 CRC64;
MCQETPPRPR APSRWTPALL ALLALGGAGL CHASSQPGYH ARPSARNKNW CAYIVNKNVS
CTVQEGSESF IQAQYNCPWN QMPCPSALVY RVNFRPRFVT RYKIVTQLEW RCCPGFRGPD
CQEGPKDHMK TPRPPSARPK NNLKKATDTD PSQVSQPKKT LSPTNAVEPG QVADAKQGPP
ELQQSKVQVL EEKVVRLTRM VLDLQSTVVG LKENLKHTIQ DDGRKEPDSW LGPLHPQPTP
DSPLAGDAEP SQLPGIPSSK ESGMKDIKSE LAEVKDTLKT KSDKLEELDG KVKGYEGQLK
QLQEAAQGPT VTMTTNELYQ AYVDSKIDAL REELMEGMDR KLADLKNTCE YKLVGLQQQC
DDYGSSYLGV IELIGEKEAS LKKDIADLRA QLQDPVAQPS CCNGQKSSDF GPQIKALDQK
IERVAEATRM LNGRLDNEFD RLSVPEPDAD FDARWTELDA RINVTEKNAE EHCFYIEETL
RGTINGEVDD LRKLLNEKIH SLEDRLGIVL QAANSSDVEL TPMGPALPEQ PGAENEQVLM
ELSRLKDKVQ VVEDFCLQSL PHGIDGALPS VEDLTHVSLS LLESLNDTMH RQFQETSHSI
QKLQEDVNAL HSQLNHSECT GTYLQNGVSD SRTGDSMEAS GFTKTGEQER TVGTVPSPGT
PAAPCCGQLE ERWQKLQNQM LAELDTCKES AHGVQSGVSA IEGRVFQLEQ TCRRLDTISG
SLQRIKEGLG KHVGSLWNCI RQMNGTLKSH SRDISGLKNS VQQFYSHVFQ ISTDLQDLVK
FQPSATEEPS EATEGPSGKT PLESTRPSEE APTEPPRLTP LPEDPAGPPQ TGQQPVLPQR
PLQPPPLPAW PGRTGLPFLP GSSGVIMETG EAGPPGRMGV SGRGLPRGVD GQMGQGPIHS
SEGYAGAPGY PKSPPVTTPG VPLPTLVSFS AGLTQKPFPS DGGVVLFNKV LVNDGDVYNP
NTGIFTAPYD GRYLITATLT PERDTYVEAV LSVSNASVAQ LHTAGYRREF LEYHRPPGAV
HTCGGPGAFH LIVHLKAGDG VNVVVTGGRL AHTDFDEMYS TFSGVFLYPF LSHL
//
