ID Q3U430_MOUSE Unreviewed; 833 AA.
AC Q3U430;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 22-FEB-2023, entry version 107.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN Name=Anapc2 {ECO:0000313|MGI:MGI:2139135};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE32605.1};
RN [1] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE32605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE32605.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AK154465; BAE32605.1; -; mRNA.
DR AlphaFoldDB; Q3U430; -.
DR EPD; Q3U430; -.
DR PeptideAtlas; Q3U430; -.
DR AGR; MGI:2139135; -.
DR MGI; MGI:2139135; Anapc2.
DR UniPathway; UPA00143; -.
DR ChiTaRS; Anapc2; mouse.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 513..711
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 474..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..494
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 95023 MW; 8D536B05E505A278 CRC64;
MEAEGVAVAA AAAAATIIAS DDCDSRPGQE LLVAWNTVST GLVPPAALGL ASSRTSGAVP
PKEEELRAAV EVLRGHGLHS VLEEWFVEVL QNDLQGNIAT EFWNAIALRE NSVDEPQCLG
LLLDAFGLLE SRLDPYLHSL ELLEKWTRLG LLMGAGAQGL REKVHTMLRG VLFFSTPRTF
QEMVQRLYGR FLRVYMQSKR KGEGGTDPEL EGELDSRYAR RRYYRLLQSP LCAGCGSDKQ
QCWCRQALEQ FNQLSQVLHR LSLLERVCAE AVTTTLHQVT RERMEDRCRG EYERSFLREF
HKWIERVVGW LGKVFLQDNP TRPTSPEAGN TLRRWRCHVQ RFFYRIYATL RIEELFSIIR
DFPDSRPAIE DLKYCLERTD QRQQLLVSLK VALETRLLHP GVNTCDIITL YISAIKALRV
LDPSMVILEV ACEPIRRYLR TREDTVRQIV AGLTGDSDGT GDLAVELSKT DPACLETGQD
SEDDSGEPED WVPDPVDADP VKSSSKRRSS DIISLLVSIY GSKDLFINEY RSLLADRLLH
QFSFSPEREI RNVELLKLRF GEAPMHFCEV MLKDMADSRR INANIREEDE KRPVEEQPPF
GVYAVILSSE FWPPFKDEKL EVPEDIRAAL DVYCKKYEKL KAMRTLSWKH TLGLVTMDVE
LADRTLSVAV TPVQAVVLLY FQNQASWTLE ELSKVVKMPV ALLRRRMSVW LQQGVLREEP
PGTFSVIEEE RPQDRDNMVL IDSDDESDSG MASQADQKEE ELLLFWAYIQ AMLTNLESLS
LERIYSMLRM FVMTGPALAE IDLQELQGYL QKKVRDQQLI YSAGVYRLPK NSN
//