ID Q3U7X3_MOUSE Unreviewed; 110 AA.
AC Q3U7X3;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=Bcl-2-like protein 11 {ECO:0008006|Google:ProtNLM};
GN Name=Bcl2l11 {ECO:0000313|MGI:MGI:1197519};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE31246.1};
RN [1] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE31246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE31246.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31246.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
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DR EMBL; AK150464; BAE29581.1; -; mRNA.
DR EMBL; AK152472; BAE31246.1; -; mRNA.
DR EMBL; AK153542; BAE32079.1; -; mRNA.
DR RefSeq; NP_033884.1; NM_009754.3.
DR AlphaFoldDB; Q3U7X3; -.
DR SMR; Q3U7X3; -.
DR MaxQB; Q3U7X3; -.
DR Antibodypedia; 3621; 1375 antibodies from 45 providers.
DR DNASU; 12125; -.
DR GeneID; 12125; -.
DR UCSC; uc008mgl.1; mouse.
DR AGR; MGI:1197519; -.
DR CTD; 10018; -.
DR MGI; MGI:1197519; Bcl2l11.
DR VEuPathDB; HostDB:ENSMUSG00000027381; -.
DR HOGENOM; CLU_104244_1_1_1; -.
DR OrthoDB; 4327858at2759; -.
DR BioGRID-ORCS; 12125; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Bcl2l11; mouse.
DR ExpressionAtlas; Q3U7X3; baseline and differential.
DR InterPro; IPR014771; Apoptosis_Bim_N.
DR InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
DR Pfam; PF08945; Bclx_interact; 1.
DR Pfam; PF06773; Bim_N; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 4..40
FT /note="Apoptosis Bim N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06773"
FT DOMAIN 43..78
FT /note="Bcl-x interacting BH3"
FT /evidence="ECO:0000259|Pfam:PF08945"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 12954 MW; 67AB421AC1E4D2CA CRC64;
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QASIRQSQEE PEDLRPEIRI
AQELRRIGDE FNETYTRRVF ANDYREAEDH PQMVILQLLR FIFRLVWRRH
//
