ID Q3UDI4_MOUSE Unreviewed; 1346 AA.
AC Q3UDI4;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=Sh3tc1 {ECO:0000313|MGI:MGI:2678949};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE29277.1};
RN [1] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE29277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29277.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29277.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
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DR EMBL; AK150064; BAE29277.1; -; mRNA.
DR RefSeq; NP_919325.2; NM_194344.2.
DR GeneID; 231147; -.
DR AGR; MGI:2678949; -.
DR CTD; 54436; -.
DR MGI; MGI:2678949; Sh3tc1.
DR OrthoDB; 5355140at2759; -.
DR BioGRID-ORCS; 231147; 2 hits in 79 CRISPR screens.
DR ChiTaRS; Sh3tc1; mouse.
DR Genevisible; Q3UDI4; MM.
DR CDD; cd11885; SH3_SH3TC; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR042772; SH3TC1/SH3TC2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22647:SF3; SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22647; SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS CONTAINING PROTEIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 309..372
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 149409 MW; 2BA8B6F96E2480D7 CRC64;
MRSFREEEEE ATSEELFTMG RGPEEPRGSC SPEDQIQSVS MGLPTGQERT GSAEAEATVR
GDVAPPRIVV GLAAEPPPSQ MTVYPTDLTL QLLAVRRKSG LRSPSLQQAL RSRLRLLEND
SREVARVLGE LSARLLSIHS DQDRIVVTFK TFEEIWKFST YHALGFTHHC LENLLVDQTF
WLLSPSEEEE TAILMYVNKD ALKQTHKNLL TQEGSIFVLC PDHRVRRTIG PKGAGKGPQT
LRRASGVPLG VAILETDSSS PTPNMSSNVE AAEAEPEPLT PFHQWTLRVP WDPIDESMSG
PGTPDAQLMR FGLASAIADF QGSGPEEMSF SVGDVIEILG AQVPGLPWCV GRHMASGQVG
FVRTGLVSMQ GPASDLESAI FLSEEERSFF RSEGHFSDED ARRLLSRTSG TDVCTTCSLD
WLEEAEGEQL EQREMSLPHL NPEPHGTLQM VKNILEKCKA CPDHPEAPVS WSLGGVSRRA
SSLDLEEPRF CLDPEDDWTD PEPLDSLLQV LNAPGYGAHF RSLYDISLPW LSTALYGFDD
EEELAERLAQ ARGVAKKVDL SMALARLCLL LGRLCARKLK LSQARVYFEE ALGALEGSFG
DLSLVAAVYS SLTTVYLKQK NAEKCVQVAP KAAALLLGTP GHSCNADAEL LKYALRRVIC
GLSPQAEARA CFLLARHYTH LKQPEEALPY LERLLRLNRD AGSPQASWPE DCYLLLADIY
GRKCLPHLAL SCLRVSSLWT RCSLPGSLRS VDLVLQNVPG PNSQRRAGHS LPSQIAYYLR
QALASLAPGT GQALRGPLYA SLAQLYSHHQ QYSQAIAFMS QAAEADTAAG VHPVVDRLVA
LAWLHMLCGN SLVAMDILKC ISDAAVANKD QECVMMNMVA MALKRMGRTR QAAEGYFRAL
HMAYAQGHLQ SQAVVLANFG ALCLQAGARS LAQHYLREAV GLFSQVPSGV CGRDFTQVLL
WLGQLCTRRA LPQQAKCYYE WAFLVAVETD HLESQLQAVQ KLCLFYSKVM PNEVRCVIYH
EFQLALARKT ANKVLEGQLL EAISQLYLSL GTERAYKSAL DYTKRSLGIF IDLQQKEKEA
RAWLQAGKIY YILRQNELVD LYIQVAQNAA LYTGDPKLGL ELFEAAGDIF FNGTWEREKA
VSFYRDRALP LAVTVGDQEV ELRLCNKLVA LLSALEAPQE GLEFAHEALA LIITLGDRLN
ERVAYHRLAT LHHRLGHGEL AEHFFLKALS LCSSPLEFDE ETLYYVKVYL VLGDIIFYDL
KDPFDAAGYY QLALAAAVDL GHKKAQLKIY TRLATIYHHF LVDREMSLFF YQKARTFASE
LNLRRTNLVP QRFCGRAPWL APGHPS
//
