ID Q3UDL6_MOUSE Unreviewed; 751 AA.
AC Q3UDL6;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 03-APR-2013, entry version 63.
DE SubName: Full=Putative uncharacterized protein;
GN Name=Aplp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to
RT prepare full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format
RT sequencing pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RG The RIKEN Genome Exploration Research Group Phase II Team and the
RG FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group
RG Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RG The FANTOM Consortium, Riken Genome Exploration Research Group and
RG Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group
RG (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
CC -!- SIMILARITY: Contains 1 BPTI/Kunitz inhibitor domain.
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DR EMBL; AK149977; BAE29207.1; -; mRNA.
DR EMBL; AK150020; BAE29245.1; -; mRNA.
DR IPI; IPI00121338; -.
DR RefSeq; NP_001095925.1; NM_001102455.1.
DR RefSeq; NP_001095926.1; NM_001102456.1.
DR UniGene; Mm.19133; -.
DR SMR; Q3UDL6; 47-139, 374-564, 720-750.
DR MEROPS; I02.016; -.
DR GeneID; 11804; -.
DR KEGG; mmu:11804; -.
DR CTD; 334; -.
DR MGI; MGI:88047; Aplp2.
DR HOGENOM; HOG000232190; -.
DR HOVERGEN; HBG000051; -.
DR KO; K08117; -.
DR ChiTaRS; APLP2; mouse.
DR NextBio; 279659; -.
DR Genevestigator; Q3UDL6; -.
DR GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
DR GO; GO:0008203; P:cholesterol metabolic process; IGI:MGI.
DR GO; GO:0009790; P:embryo development; IGI:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IGI:MGI.
DR GO; GO:0030900; P:forebrain development; IGI:MGI.
DR GO; GO:0007626; P:locomotory behavior; IGI:MGI.
DR GO; GO:0007617; P:mating behavior; IGI:MGI.
DR GO; GO:0030901; P:midbrain development; IGI:MGI.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
DR GO; GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; IGI:MGI.
DR GO; GO:0043393; P:regulation of protein binding; IGI:MGI.
DR GO; GO:0001967; P:suckling behavior; IGI:MGI.
DR Gene3D; 3.30.1490.140; -; 1.
DR Gene3D; 3.90.570.10; -; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR008155; Amyloid_glyco.
DR InterPro; IPR011178; Amyloid_glyco_Cu-bd.
DR InterPro; IPR024329; Amyloid_glyco_E2_domain.
DR InterPro; IPR008154; Amyloid_glyco_extra.
DR InterPro; IPR019744; Amyloid_glyco_extracell_CS.
DR InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR InterPro; IPR019745; Amyloid_glyco_intracell_CS.
DR InterPro; IPR019543; APP_amyloid_C.
DR InterPro; IPR002223; Prot_inh_Kunz-m.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR Pfam; PF10515; APP_amyloid; 1.
DR Pfam; PF12924; APP_Cu_bd; 1.
DR Pfam; PF12925; APP_E2; 1.
DR Pfam; PF02177; APP_N; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00203; AMYLOIDA4.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00006; A4_EXTRA; 1.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF56491; A4_extra; 1.
DR SUPFAM; SSF89811; Amyloid_glyco_Cu-bd; 1.
DR SUPFAM; SSF57362; Prot_inh_Kunz-m; 1.
DR SUPFAM; SSF109843; SSF109843; 1.
DR PROSITE; PS00319; A4_EXTRA; 1.
DR PROSITE; PS00320; A4_INTRA; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 2: Evidence at transcript level;
SQ SEQUENCE 751 AA; 85176 MW; 184E6A7D608BF083 CRC64;
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI TNVMEANQPV NIDSWCRRDK
RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ FFHQERMEVC EKHQRWHTLV KEACLTEGLT
LYSYGMLLPC GVDQFHGTEY VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF
PTEADLEDFT EAAADEEEED EEEGEGVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
EIVHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
NLPKTERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRI ALENYLAALQ
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTSSIS ENPVDVRVSS EESEEIPPFH
PLHPFPSLSE NEGSGMAEQD GGLIGAEEKV INSKNKMDEN MVIDETLDVK EMIFNAERVG
GLEEEPESVG PLREDFSLSS NALIGLLVIA VAIATVIVIS LVMLRKRQYG TISHGIVEVD
PMLTPEERHL NKMQNHGYEN PTYKYLEQMQ I
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