ID Q3UHH6_MOUSE Unreviewed; 1496 AA.
AC Q3UHH6;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 135.
DE RecName: Full=T-lymphoma invasion and metastasis-inducing protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=Tiam1 {ECO:0000313|MGI:MGI:103306};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE27881.1};
RN [1] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE27881.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE27881.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
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DR EMBL; AK147392; BAE27881.1; -; mRNA.
DR RefSeq; NP_001139358.1; NM_001145886.1.
DR RefSeq; NP_001139359.1; NM_001145887.1.
DR RefSeq; NP_033410.2; NM_009384.3.
DR EPD; Q3UHH6; -.
DR DNASU; 21844; -.
DR GeneID; 21844; -.
DR KEGG; mmu:21844; -.
DR AGR; MGI:103306; -.
DR CTD; 7074; -.
DR MGI; MGI:103306; Tiam1.
DR OrthoDB; 25601at2759; -.
DR BioGRID-ORCS; 21844; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Tiam1; mouse.
DR Genevisible; Q3UHH6; MM.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 344..452
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 670..737
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 750..813
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 945..1139
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 210..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 458..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 210..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1496 AA; 166909 MW; 7BB89C7D7A2D89A4 CRC64;
MGLRPVSYTD SSVTPSVDGS IVLTAASVQS MPDSEESRLY GDDATYLAEG GRRQCPYTSN
GPTFMETASF KKKRSKSADI WREDSLEFSL SDLSQEHLTS NEEILGSAEE KDCEEARGME
TEASPRQLST CQRANSLGDL YAQKNSGVKA NGGPRNRFSS YCRNLVSDIP DLAKHKMPPA
AAEETPPYSN YNTLPCRKSH CLSEGATNPQ ISLSKSMQGR RAKTTQDVNT GEGSEFADSG
IEGATTDTDL LSRRSNATNS SYSPPTGRAF VGSDSGSSST GDAARQGVYE NFRRELEMST
TNSESLEEAG SAHSDEQSSG TLSSPGQSDI LLTAAQGTVR KAGALAVKNF LVHKKNKKVE
SATRRKWKHY WVSLKGCTLF FYETDGRSGI DHNSVPKHAV WVENSIVQAV PEHPKKDFVF
CLSNSLGDAF LFQTTSQTEL ENWITAIHSA CAAAVARHHH KEDTLRLLKS EIKKLEQKID
MDEKMKKMGE MQLSSVTDSK KKKTILDQIF VWEQNLEQFQ MDLFRFRCYL ASLQGGELPN
PKRLLAFASR PTKVAMGRLG IFSVSSFHAL VAARTGEIGV RRRTQAMSRS ASKRRSRFSS
LWGLDTTSKK KQGRPTINQV FGEGTDAVKR SLEGIFDDTV PDGKREKEVV LPSVHQHNPD
CDIWVHEYFT PSWFCLPNNQ PALTVVRPGD TARDTLELIC KTHQLDHSAH YLRLKFLMEN
RVQFYIPQPE EDIYELLYKE IEICPKVTQN IHIEKSDAAA DNYGFLLSSV DEDGIRRLYV
NSVKETGLAS KKGLKAGDEI LEINNRAAGT LNSSMLKDFL SQPSLGLLVR TYPEPEGGVE
LLENPPHRVD GPVDLGESPL AFLTSNPGHS LSSEQGSSAE TAPEEGEGPD LESSDETDHS
SKSTEQVAAF CRSLHEMSPS DSSPSPQDAT SPQLATTRQL SDADKLRKVI CELLETERTY
VKDLNCLMER YLKPLQKETF LTQDELDVLF GNLTEMVEFQ VEFLKTLEDG VRLVPDLEKL
EKVDQFKKVL FSLGGSFLYY ADRFKLYSAF CASHTKVPKV LVKAKTDTAF KAFLDAQNPR
QQHSSTLESY LIKPIQRVLK YPLLLRELFA LTDAESEEHY HLDVAIKTMN KVASHINEMQ
KIHEEFGAVF DQLIAEQTGE KKEVADLSMG DLLLHTSVIW LNPPASLGKW KKEPELAAFV
FKTAVVLVYK DGSKQKKKLV GSHRLSIYEE WDPFRFRHMI PTEALQVRAL PSADAEANAV
CEIVHVKSES EGRPERVFHL CCSSPESRKD FLKSVHSILR DKHRRQLLKT ESLPSAQQYV
PFGGKRLCAL KGARPAMSRA VSAPSKSLGR RRRRLARNRF TIDSDAISAS SPEKEPQQPA
GGGDTDRWVE EQFDLAQYEE QDDIKETDIL SDDDEFCESL KGASVDRDLQ EQLQAASISQ
RARGRRTLDS HASRMTQLKK QAALSGINGG LESASEEVIW VRREDFAPSR KLNTEI
//
